(9S,9aS)-9-(3,5-difluorophenoxy)-4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,6,7,8,9,9a-hexahydropyrido[1,2-d][1,2,4]oxadiazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (9S,9aS)-9-(3,5-difluorophenoxy)-4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,6,7,8,9,9a-hexahydropyrido[1,2-d][1,2,4]oxadiazine
• 化学式: C₂₄H₂₄F₂N₄O₃
• 分子量: 454.5
• InChiKey: HHWLETTXTIXYBO-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• GAMMA SECRETASE MODULATORS
  申请人：MANDAL MIHIR B.

  公开号：US20160304534A1

  公开（公告）日：2016-10-20

  Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.
• US9598437B2
  申请人：——

  公开号：US9598437B2

  公开（公告）日：2017-03-21
• [EN] GAMMA SECRETASE MODULATORS<br/>[FR] MODULATEURS DE LA SÉCRÉTASE GAMMA
  申请人：MERCK SHARP & DOHME

  公开号：WO2015084752A1

  公开（公告）日：2015-06-11

  Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.