5-pyrrolidino-pentan-2-one | 59127-77-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-pyrrolidino-pentan-2-one
• 英文别名: 5-Pyrrolidino-pentan-2-on；5-(Pyrrolidin-1-yl)pentan-2-one；5-pyrrolidin-1-ylpentan-2-one
• CAS: 59127-77-4
• 化学式: C₉H₁₇NO
• 分子量: 155.24
• InChiKey: KLTKVHXJBZRLNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-pyrrolidino-pentan-2-one 在 甲醇 、 镍 作用下， 100.0 ℃ 、7.35 MPa 条件下， 生成 5-pyrrolidino-pentan-2-ol
  参考文献：
  名称：

  PYRROLIDYL ALKANOLS

  摘要：

  DOI：

  10.1021/jo01157a020
• 作为产物：
  描述：

  N-(2-氯乙基)吡咯烷 、 乙酰乙酸乙酯钠 在 苯 作用下， 生成 5-pyrrolidino-pentan-2-one
  参考文献：
  名称：

  Synthesis of 7-Chloro-4-[1-methyl-(1-pyrrolidyl)-butylamino]-quinoline

  摘要：

  DOI：

  10.1021/ja01170a517

文献信息

• Bicyclic piperazine compound and use thereof
  申请人：Fukatsu Kohji

  公开号：US20070072865A1

  公开（公告）日：2007-03-29

  The present invention provides a compound represented by the formula: wherein R 1 is an acyl group, R 2 is a hydrocarbon group which may be substituted or the like, R 3 is a hydrocarbon group which may be substituted or the like, R 4 is a hydrocarbon group which may be substituted or the like, n is from 0 to 4, and X is an oxygen atom, a sulfur atom or the like, or a salt thereof. The invention also provides a compound which has a TGR23 antagonist activity and thus is useful for prevention and treatment of cancer.

  本发明提供一种化合物，其化学式为：其中，R1是酰基，R2是烃基，可以被取代或类似物，R3是烃基，可以被取代或类似物，R4是烃基，可以被取代或类似物，n为0至4，X为氧原子、硫原子或类似物或其盐。本发明还提供一种具有TGR23拮抗活性的化合物，因此可用于预防和治疗癌症。
• Biphenyl compounds useful as muscarinic receptor antagonists
  申请人：Mammen Mathai

  公开号：US20070293461A1

  公开（公告）日：2007-12-20

  This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

  该发明提供了I式化合物，其中a、b、c、d、m、n、p、r、R1、R2、R3、R4、R5、R6、R7和W的定义如规范中所述。I式化合物是肌肉制动受体拮抗剂。该发明还提供了含有这种化合物的药物组合物，制备这种化合物的过程和中间体以及使用这种化合物治疗肺部疾病的方法。
• BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：MAMMEN Mathai

  公开号：US20110059931A1

  公开（公告）日：2011-03-10

  This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

  该发明提供了I式化合物：其中a，b，c，d，m，n，p，r，R1，R2，R3，R4，R5，R6，R7和W的定义如规范中所述。I式化合物是肌肉型受体拮抗剂。该发明还提供了含有这种化合物的制药组合物，制备这种化合物的过程和中间体以及使用这种化合物治疗肺部疾病的方法。
• [EN] PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF<br/>[FR] COMPOSÉ DE PYRROLOPYRIDAZINE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION<br/>[ZH] 一种吡咯并哒嗪类化合物及其制备方法和用途
  申请人：HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO LTD

  公开号：WO2022166920A1

  公开（公告）日：2022-08-11

  涉及式(I)所示的吡咯并哒嗪类化合物或其药学上可接受的盐，还涉及所述化合物的药物制剂、药物组合物及其应用，所述化合物可用于制备治疗或者预防由HPK1介导的相关疾病。
• COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY
  申请人：Siddiqui M. Arshad

  公开号：US20110123435A1

  公开（公告）日：2011-05-26

  The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and to methods for their use in inhibiting KSP kinesin activity, and for treating cellular proliferative diseases or disorders associated with KSP kinesin activity. Formula I