[2-(4-Chlorophenyl)-2-oxoethyl] 2-[3-[(2,6-dichlorophenyl)methyl]-4-methyl-2-oxochromen-7-yl]oxyacetate | 353477-88-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-(4-Chlorophenyl)-2-oxoethyl] 2-[3-[(2,6-dichlorophenyl)methyl]-4-methyl-2-oxochromen-7-yl]oxyacetate
• CAS: 353477-88-0
• 化学式: C₂₇H₁₉Cl₃O₆
• 分子量: 545.8
• InChiKey: RPAVSHXRRPIVFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF
  申请人：CONSIGLIO NAZIONALE DELLE RICERCHE

  公开号：US20170003275A1

  公开（公告）日：2017-01-05

  The invention refers to a method for identifying an anti-tumoral and/or anti-proliferative and/or an inhibitor of the fission machinery involved in mitotic Golgi partitioning and/or a molecule modulator of CtBP corepressor activity by testing their affinity binding for the Rossmann fold of C-terminal-binding proteins (CtBPs); to said identified molecules and to the use thereof as anti-proliferative and/or anti tumoral agents.
• [EN] METHOD TO IDENTIFY COMPOUNDS ABLE TO BIND TO THE ROSSMANN FOLD OF C-TERMINAL-BINDING PROTEINS, IDENTIFIED COMPOUNDS AND MEDICAL USES THEREOF<br/>[FR] PROCEDE POUR IDENTIFIER DES COMPOSES APTES A SE LIER A UN PLI DE ROSSMANN DE PROTEINES DE LIAISON C–TERMINAL, COMPOSES IDENTIFIES ET LEURS UTILISATIONS MEDICALES
  申请人：CONSIGLIO NAZIONALE RICERCHE

  公开号：WO2014184370A1

  公开（公告）日：2014-11-20

  The invention refers to a method for identifying an anti-tumoral and/or anti-proliferative and/or an inhibitor of the fission machinery involved in mitotic Golgi partitioning and/or a molecule modulator of CtBP corepressor activity by testing their affinity binding for the Rossmann fold of C-terminal-binding proteins (CtBPs); to said identified molecules and to the use thereof as anti-proliferative and/or anti tumoral agents.