4-acetyl-N-[1-(1H-indol-3-yl)propan-2-yl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-N-[1-(1H-indol-3-yl)propan-2-yl]benzenesulfonamide
• 化学式: C₁₉H₂₀N₂O₃S
• 分子量: 356.4
• InChiKey: ZXDCEKGFQSQQRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  87.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] -3 (SULFONAMIDOETHYL) -INDOLE DERIVATIES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES<br/>[FR] DERIVES DE -3 (SULFONAMIDOETHYL) -INDOLE DESTINES A ETRE UTILISES COMME AGENTS MIMETIQUES GLUCOCORTICOIDES DANS LE TRAITEMENT DES MALADIES INFLAMMATOIRES, ALLERGIQUES ET PROLIFERATIVES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2004019935A1

  公开（公告）日：2004-03-11

  Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Y are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  式（I）中的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、X和Y如本文所定义，或其互变异构体、前药、溶剂合物或盐；包含这种化合物的药物组合物，以及使用这些化合物调节糖皮质激素受体功能的方法，以及使用这些化合物治疗由糖皮质激素受体功能介导或以炎症、过敏或增生过程为特征的疾病状态或情况的方法。
• Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20040097574A1

  公开（公告）日：2004-05-20

  Compounds of Formula (I) 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , X, and Y are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  化合物公式(I)的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、X和Y如本文所定义，或其互变异构体、前药、溶剂化物或盐；包含这些化合物的药物组合物，以及使用这些化合物调节糖皮质激素受体功能或治疗由糖皮质激素受体功能介导或以炎症、过敏或增殖过程为特征的疾病状态或病情的方法。
• -3 (SULFONAMIDOETHYL) -INDOLE DERIVATIES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1539141A1

  公开（公告）日：2005-06-15
• 3-(SULFONAMIDOETHYL)-INDOLE DERIVATIVES FOR USE AS GLUCOCORTICOID MIMETICS IN THE TREATMENT OF INFLAMMATORY, ALLERGIC AND PROLIFERATIVE DISEASES
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：EP1539141B1

  公开（公告）日：2010-07-14