(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[2-[(E)-[(E)-[2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methylidenehydrazinylidene]methyl]phenoxy]oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[2-[(E)-[(E)-[2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]methylidenehydrazinylidene]methyl]phenoxy]oxane-3,4,5-triol
• 化学式: C₂₆H₃₂N₂O₁₂
• 分子量: 564.5
• InChiKey: ZGTFPSNGHZSMHL-HJGGRDRJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  224
• 氢给体数：
  8
• 氢受体数：
  14

文献信息

• METHOD USING FLUORESCENT TURN-ON PROBES FOR CELL-SPECIFIC DETECTION
  申请人：Agency for Science, Technology and Research

  公开号：US20150192589A1

  公开（公告）日：2015-07-09

  The invention provides method for imaging the activity of enzymes or bioactive molecules in cells using fluorescent probes with aggregation-induced emission properties and excited-state intramolecular proton transfer properties. The fluorescent probes prepared according to the invention are those of formula (I), wherein W, X, Y, Z have the meaning as described in the description, R is a reactive group that can interact with enzymes and other bioactive molecules, Linker is a single bond or a combination of chemical bonds linking the targeting group T to the probe molecule, and T represents a targeting group that has an ability to interact with an organelle.

  本发明提供了一种利用具有聚集诱导发光性质和激发态分子内质子转移性质的荧光探针来成像细胞内酶或生物活性分子活性的方法。根据本发明制备的荧光探针是式（I）所示的那种，其中W、X、Y、Z的含义如描述所述，R是可以与酶和其他生物活性分子相互作用的反应性基团，连接基是将靶向基团T与探针分子连接的单键或化学键的组合，T代表具有与细胞器相互作用能力的靶向基团。