3,3'-dimethoxy-2,2'-bipyrazine | 1197343-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,3'-dimethoxy-2,2'-bipyrazine
• 英文别名: 2-Methoxy-3-(3-methoxypyrazin-2-yl)pyrazine；2-methoxy-3-(3-methoxypyrazin-2-yl)pyrazine
• CAS: 1197343-82-0
• 化学式: C₁₀H₁₀N₄O₂
• 分子量: 218.215
• InChiKey: URUCRFYBHMWZHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-甲氧基吡嗪 在 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex 、 氧气 、 copper dichloride 、 zinc(II) chloride 作用下， 20.0 ℃ 、101.33 kPa 条件下， 以50%的产率得到3,3'-dimethoxy-2,2'-bipyrazine
  参考文献：
  名称：

  An Aromatic Glaser−Hay Reaction

  摘要：

  A general method for copper-catalyzed deprotonative dimerization of arenes by employing oxygen as the terminal oxidant has been developed. Electron-rich and electron-poor heterocycles as well as electron-poor arenes are reactive. The method is tolerant to functionalities such as nitro, cyano, dialkylamino, and ester groups.

  DOI：

  10.1021/ja907479j

文献信息

• An Aromatic Glaser−Hay Reaction
  作者：Hien-Quang Do、Olafs Daugulis

  DOI：10.1021/ja907479j

  日期：2009.12.2

  A general method for copper-catalyzed deprotonative dimerization of arenes by employing oxygen as the terminal oxidant has been developed. Electron-rich and electron-poor heterocycles as well as electron-poor arenes are reactive. The method is tolerant to functionalities such as nitro, cyano, dialkylamino, and ester groups.
• C5A RECEPTOR MODULATORS
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：US20200347029A1

  公开（公告）日：2020-11-05

  The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R 1 , R 2 , R 3 and R 4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.
• Nickel, Manganese, Cobalt, and Iron-Catalyzed Deprotonative Arene Dimerization
  作者：Thanh Truong、Joseph Alvarado、Ly Dieu Tran、Olafs Daugulis

  DOI：10.1021/ol902970z

  日期：2010.3.19

  A number of first-row transition metal salts catalyze deprotonative dimerization of acidic arenes. Under the atmosphere of oxygen, nickel, manganese, cobalt, and Iron chlorides have been shown to dimerize five- and six-membered ring heterocycles as well as electron-poor arenes. Both tetramethylpiperidide and dicyclohexylamide bases can be employed; however, the former afford slightly higher yields.