7-(甲氨基)庚酸 | 90227-27-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 7-(甲氨基)庚酸
• 英文名称: 7-Methylamino-heptansaeure
• 英文别名: 7-(Methylamino)heptanoic acid
• CAS: 90227-27-3
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: KBMWCYLQINPRTE-UHFFFAOYSA-N

物化性质

• 熔点：
  96-97 °C
• 沸点：
  272.3±23.0 °C(Predicted)
• 密度：
  0.970±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-(甲氨基)庚酸 在 palladium on activated charcoal lithium hydroxide 、 正丁基锂 、 2,4,6-三异丙基苯磺酰叠氮化物 、 氢气 、 双氧水 、 三甲基乙酰氯 、 双(三甲基硅烷基)氨基钾 、 碳酸氢钠 、 三乙胺 作用下， 生成
  参考文献：
  名称：

  Asymmetric synthesis of non-natural homologues of lysine

  摘要：

  A series of non-natural amino acid homologues of L- and D-lysine have been synthesized and protected for use in solid-phase peptide synthesis. With these residues, electrostatics and hydrophobicity of peptides can be enhanced or altered. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00335-1
• 作为产物：
  描述：

  7-氯庚醇腈 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 7-(甲氨基)庚酸
  参考文献：
  名称：

  Amination of 7 -chloroheptanenitrile-product of the telomerization of ethylene with cyanogen chloride

  摘要：

  DOI：

  10.1007/bf00863117

文献信息

• Separation material comprising phosphoryl choline derivatives
  申请人：Pentracor GmbH

  公开号：EP2957563A1

  公开（公告）日：2015-12-23

  The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material, which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also claimed is a device containing a column that comprises separation material made from formula (I) wherein L is a linker as defined in the claims; X is selected from: -SH, -NHR3, -C=CH, -CH=CH2, -N3, -CHO. Also claimed is a separation material of general formula (II): wherein A is a solid support; Y is a group obtainable from the reactive group X.

  本发明提供了一般式（I）的磷酸胆碱衍生物，适合固定在固体支架上，以提供分离材料，其具有与蛋白质高亲和力和高特异性结合的能力，更具体地结合到C-反应蛋白和抗磷酸胆碱抗体。该分离材料在从患者的生物液中外体清除C-反应蛋白和抗磷酸胆碱抗体，以预防和/或治疗免疫功能障碍和心血管疾病方面特别有用。还声明了一种包含由公式（I）制成的分离材料的柱子的装置，其中L是如权利要求中定义的连接剂;X选自：-SH，-NHR3，-C = CH，-CH = CH2，-N3，-CHO。还声明了一种一般式（II）的分离材料：其中A是固体支架; Y是从反应基团X获得的基团。
• PYRIMIDINE COMPOUND
  申请人：Matsushima Yuji

  公开号：US20110053912A1

  公开（公告）日：2011-03-03

  A novel and excellent method for preventing and/or treating diseases related to a cannabinoid type 2 receptor, based on an agonistic action on a cannabinoid type 2 receptor. It was found that a hetero ring derivative mainly having two substituents, for example, a pyrimidine-5-carboxamide derivative having a substituent amino group at the 2-position, exhibits a potent agonistic action on a cannabinoid type 2 receptor, and can be an agent for preventing and/or treating diseases related to a cannabinoid type 2 receptor such as inflammatory diseases, pain, and the like.

  一种预防和/或治疗与大麻素2型受体相关疾病的新颖优秀方法，基于对大麻素2型受体的激动作用。发现一种异核环衍生物主要具有两个取代基，例如，在2-位置具有取代基氨基的嘧啶-5-羧酰胺衍生物，表现出对大麻素2型受体的强效激动作用，可以成为预防和/或治疗与大麻素2型受体相关疾病，如炎症性疾病、疼痛等的药物。
• ORALLY AVAILABLE VIRIDIOFUNGIN DERIVATIVE POSSESSING ANTI-HCV ACTIVITY
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20150210666A1

  公开（公告）日：2015-07-30

  An object of the present invention is to provide a compound that is useful as an orally available anti-HCV agent. The present invention relates to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. This compound has an anti-HCV activity and is useful as a medicine.

  本发明的目的是提供一种可口服的抗丙型肝炎病毒药物化合物。本发明涉及一种由式（1）所表示的化合物或其药学上可接受的盐。该化合物具有抗丙型肝炎病毒的活性，是一种有用的药物。
• PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS
  申请人：G.D. Searle & Co.

  公开号：EP0910351A1

  公开（公告）日：1999-04-28
• SEPARATION MATERIAL COMPRISING PHOSPHORYL CHOLINE DERIVATIVES
  申请人：Pentracor GmbH

  公开号：EP3041852A1

  公开（公告）日：2016-07-13