3-(3-Fluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one | 590419-78-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(3-Fluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one
• 英文别名: 3-(3-fluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one
• CAS: 590419-78-6
• 化学式: C₁₅H₁₀F₂O
• 分子量: 244.241
• InChiKey: QAOGPZYAKOBUEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-Fluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one 在 三乙胺 、 potassium hydroxide 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 1.0h， 生成 N-(5-(3-fluorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonothioyl)-4-methyl-N-(4-methylbenzoyl)benzamide
  参考文献：
  名称：

  Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies

  摘要：

  新合成的吡唑啉酰基硫脲类化合物的 IC50 值显示，5b 和 5g 是强效的脲酶抑制剂。化合物 5b 是一种强效的 α-葡萄糖苷酶抑制剂，化合物 5f 是一种强效的淀粉酶抑制剂，化合物 5b 则是一种强效的抗氧化剂。

  DOI：

  10.1039/d3ra06812a
• 作为产物：
  描述：

  4-氟苯乙酮 、 3-氟苯甲醛 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 生成 3-(3-Fluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one
  参考文献：
  名称：

  Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies

  摘要：

  新合成的吡唑啉酰基硫脲类化合物的 IC50 值显示，5b 和 5g 是强效的脲酶抑制剂。化合物 5b 是一种强效的 α-葡萄糖苷酶抑制剂，化合物 5f 是一种强效的淀粉酶抑制剂，化合物 5b 则是一种强效的抗氧化剂。

  DOI：

  10.1039/d3ra06812a

文献信息

• ANTI-INVASIVE COMPOUNDS
  申请人：Universiteit Gent

  公开号：US20150011620A1

  公开（公告）日：2015-01-08

  The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.

  本发明涉及抗侵袭化合物领域，以及预测该类化合物抗侵袭活性的方法，以及它们在预防和/或治疗与不受欢迎的细胞侵袭相关的疾病中的用途；特别是，本发明涉及抗侵袭的类似香豆素化合物领域。
• Synthesis and Spectral Studies of Some New bis(1,3‐Diketonato)palladium(II) Complexes
  作者：Vijai N. Pathak、Chandra K. Oza、Ragini Gupta、Ranjana Tiwari、Sarita Chaudhary

  DOI：10.1081/sim-120020327

  日期：2003.1.6

  Bis(1,3-diketonato)palladium(II) complexes were synthesized by three routes. In route one, sodium hexachlorodipalladate in methanol was treated with the appropriately substituted diaryl-1,3-diketones using sodium carbonate, while in route two substituted diaryl-1,3-diketones were treated with palladium chloride in acetone to afford the desired bis(1,3-diketonato)palladium(II). In route three 1,3-bis(substituted aryl)prop-2-enones were treated with palladium chloride and sodium hydrogen carbonate in THF to provide the oxygen insertion product, bis(1,3-diketonato)palladium(II) complexes. All synthesized compounds were characterized on the basis of spectral and analytical data.
• US8895578B2
  申请人：——

  公开号：US8895578B2

  公开（公告）日：2014-11-25
• US9290427B2
  申请人：——

  公开号：US9290427B2

  公开（公告）日：2016-03-22
• [EN] ANTI-INVASIVE COMPOUNDS<br/>[FR] COMPOSÉS ANTI-INVASIFS
  申请人：UNIV GENT

  公开号：WO2013113722A1

  公开（公告）日：2013-08-08

  The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.