1-[4-[(1,3,3-Trimethyl-6-azabicyclo[3.2.1]octan-6-yl)sulfonyl]phenyl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[(1,3,3-Trimethyl-6-azabicyclo[3.2.1]octan-6-yl)sulfonyl]phenyl]ethanone
• 化学式: C₁₈H₂₅NO₃S
• 分子量: 335.5
• InChiKey: KAFKJWKZTUZLKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 6-SUBSTITUTED SULFONYL AZABICYCLO[3.2.1]OCTANES USEFUL TO INHIBIT 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE-1<br/>[FR] SULFONYL-AZABICYCLO[3.2.1]OCTANES SUBSTITUÉS EN POSITION 6 UTILES POUR INHIBER LA 11B-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1
  申请人：SCHERING CORP

  公开号：WO2009023181A1

  公开（公告）日：2009-02-19

  In its many embodiments, the present invention relates to a novel class of 6-substituted sulfonyl-1,3,3-trialkyl-6-azabicyclo[3.2.1]octane compounds useful to inhibit 11β-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11β-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.

  在其许多实施方式中，本发明涉及一种新型的6-取代磺酰基-1,3,3-三烷基-6-氮杂双环[3.2.1]辛烷化合物，用于抑制11β-羟类固醇脱氢酶I型，含有该化合物的制药组合物，以及使用这种化合物或制药组合物进行治疗、预防、抑制或改善与11β-羟类固醇脱氢酶I型表达有关的一种或多种情况的方法。
• 6-SUBSTITUTED SULFONYL AZABICYCLOÝ3.2.1¨OCTANES USEFUL TO INHIBIT 11 -HYDROXYSTEROID DEHYDROGENASE TYPE-1
  申请人：Schering Corporation

  公开号：EP2188293A1

  公开（公告）日：2010-05-26
• 6-SUBSTITUTED SULFONYL AZABICYCLO[3.2.1]OCTANES USEFUL TO INHIBIT 11Beta-HYDROXYSTEROID DEHYDROGENASE TYPE-1
  申请人：Boyle Craig D.

  公开号：US20110237559A1

  公开（公告）日：2011-09-29

  In its many embodiments, the present invention relates to a novel class of 6-substituted sulfonyl-1,3,3-trialkyl-6-azabicyclo[3.2.1]octane compounds useful to inhibit 11β-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11β-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.
• US8466149B2
  申请人：——

  公开号：US8466149B2

  公开（公告）日：2013-06-18