3-(5-sulfanylidene-2H-tetrazol-1-yl)benzoic acid | 15909-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(5-sulfanylidene-2H-tetrazol-1-yl)benzoic acid
• CAS: 15909-66-7
• 化学式: C₈H₆N₄O₂S
• 分子量: 222.227
• InChiKey: FZLLHXXADRILOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(5-sulfanylidene-2H-tetrazol-1-yl)benzoic acid 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以95%的产率得到3-{5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazol-5-yl}benzoic acid
  参考文献：
  名称：

  1-取代的5-[（3,5-二硝基苄基）硫烷基] -1 H-四唑及其等排类似物：一类新型的选择性抗结核药，对药物敏感和耐多药分枝杆菌有活性

  摘要：

  在这项工作中，描述了一类新型的高效抗结核药，即1-取代的5-[（3,5-二硝基苄基）硫烷基] -1 H-四唑及其氧杂和硒基类似物。最小抑菌浓度（MIC）值达到了1μM（0.36-0.44微克/毫升）对结核分枝杆菌CNCTC我八十八分之三百三十一和0.25-1μM针对六个多药耐药性临床分离菌株的结核分枝杆菌。这些化合物的抗分枝杆菌作用具有高度特异性，因为它们对所研究的所有八种细菌菌株和八种真菌菌株均无效。此外，这些化合物在四种哺乳动物细胞系中均表现出较低的体外毒性（IC 50 > 30μM）。我们还检查了化合物的结构-活性关系，特别是硝基基团的数量和位置，四唑和苄基部分之间的连接基以及四唑本身对抗分枝杆菌活性的影响。在不对分枝杆菌活性产生负面影响的情况下，四唑上取代基R 1的相对较高的变异性可进一步优化毒性，并进一步优化1-取代的5-[（3,5-二硝基苄基）硫烷基]-的ADME性质。 1 H-四唑化合物。

  DOI：

  10.1016/j.ejmech.2014.05.069
• 作为产物：
  描述：

  3-乙氧基羰基苯异硫氰酸酯 生成 3-(5-sulfanylidene-2H-tetrazol-1-yl)benzoic acid
  参考文献：
  名称：

  KAMEOKA, KIMITAKA;INOUE, NOBUAKI;INAGAKI, YOSHIO;KOBAYASHI, HIDETOSHI;TAK+

  摘要：

  DOI：

文献信息

• Silver halide photographic light sensitive materials
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04724199A1

  公开（公告）日：1988-02-09

  A silver halide photographic light-sensitive material containing, in at least one layer thereof, a compound capable of releasing a fogging agent upon an oxidation-reduction reaction with an oxidation product of a developing agent under an alkaline condition. The material has an increased sensitivity, an increased contrast and an accelerated development rate.

  一种含有银卤化物的光敏感摄影材料，至少在其中一层中含有一种化合物，该化合物能够在碱性条件下与显影剂的氧化产物发生氧化还原反应并释放起雾剂。该材料具有增强的灵敏度、增强的对比度和加速的显影速率。
• Silver halide color light sensitive material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04734357A1

  公开（公告）日：1988-03-29

  A silver halide color light-sensitive material is described, which is increased in sensitivity, is adapted to form an image of high contrast, or is accelerated in development by incorporating a small amount of a specific compound which imagewise releases a foggant or a development accelerator. This compound is represented by the formula: Coup-(TIME).sub.n -FA (wherein Coup represents a coupler radical capable of undergoing a coupling reaction with an oxidized product of an aromatic primary amine developing agent; TIME represents a timing group which is eliminated from Coup by the coupling reaction and, thereafter, releases FA; n is 0 or 1; and FA represents a group which is eliminated from Coup in the coupling reaction when n is 0, whereas FA is released from TIME when n is 1. The FA has adsorption properties with respect to silver halide grains and also has a substantial fogging action with respect to the silver halide grains).

  本文描述了一种银卤化物彩色感光材料，通过加入少量的特定化合物，可以增加其灵敏度、适用于高对比度的图像形成，或者加速显影过程。该化合物的化学式为：Coup-(TIME).sub.n -FA，其中Coup代表一个偶联试剂基团，能够与芳香族一级胺显影剂的氧化产物发生偶联反应；TIME代表一个计时基团，通过偶联反应从Coup中消除，并随后释放FA；n为0或1；FA代表在n为0时从Coup中消除的基团，而在n为1时从TIME中释放的基团。FA对银卤化物颗粒具有吸附特性，并且对银卤化物颗粒具有显著的起雾作用。
• Silver halide photographic materials
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04737452A1

  公开（公告）日：1988-04-12

  A silver halide photographic material comprising a support having at least one silver halide emulsion layer containing substantially surface latent image type silver halide grains, said emulsion layer or at least one hydrophilic colloid layer adjacent to the emulsion layer containing a compound represented by general formula (III): ##STR1## wherein L.sub.2 represents --CONR--, --SO.sub.2 NR-- or --NRCONR' and Z, L.sub.1, m, Ro, R.sub.1 and M are as herein described. The silver halide photographic material is capable of having high contrast negative images, high sensitive negative images, and good dot images.

  一种银卤片光敏材料，包括至少一层银卤乳剂层的支撑，该银卤乳剂层包含基本表面潜影像型银卤晶粒，该乳剂层或至少一个与其相邻的亲水胶体层包含由通式（III）表示的化合物：##STR1## 其中L.sub.2表示--CONR--，--SO.sub.2 NR--或--NRCONR'，Z，L.sub.1，m，Ro，R.sub.1和M如本文所述。该银卤片光敏材料能够产生高对比度的负像，高灵敏度的负像和良好的点阵图像。
• Silver halide color photographic light-sensitive material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04628024A1

  公开（公告）日：1986-12-09

  A silver halide color photographic light-sensitive material comprising a support having thereon a silver halide emulsion layer and a compound represented by the following general formula (I): ##STR1## wherein COUP represents a coupler residue capable of being subjected to a coupling reaction with an oxidation product of an aromatic primary amine developing agent; TIME represents a timing group which is released upon the coupling reaction and subsequently releases ##STR2## Z represents a monocyclic or condensed heterocyclic ring consisting of a nitrogen atom and a carbon atom; L represents a divalent linking group; R.sup.1 represents a hydrogen atom or an alkoxycarbonyl group; R.sup.2 represents a hydrogen atom, an alkyl group, an aryl group, a heterocyclic group, an acyl group, a sulfonyl group, an alkoxycarbonyl group, a carbamoyl group, a sulfamoyl group, a thioacyl group or a thiocarbamoyl group; R.sup.3 represents a hydrogen atom; R.sup.2 and R.sup.3 may be bonded each other to form a hydrazone structure; a part of L and R.sup.1 may be bonded each other to form a hydrazone structure; and n represents 0 or 1. The silver halide color photographic light-sensitive material containing the compound capable of imagewise releasing a fogging agent represented by the general formula (I) is improved in stability during preservation and has a high contrast and sensitivity. A method of forming a color image using the silver halide color photographic light-sensitive material is also disclosed.

  一种银卤化物彩色摄影感光材料，包括支撑物上的银卤化物乳液层和下列一般式（I）所代表的化合物：##STR1##其中COUP代表能够与芳香族原始胺显影剂的氧化产物进行偶联反应的偶联剩基；TIME代表在偶联反应中释放并随后释放##STR2##的定时组；Z代表由一个氮原子和一个碳原子组成的单环或缩合杂环；L代表二价连结基；R.sUP.1代表氢原子或烷氧羰基基团；R.sUP.2代表氢原子、烷基、芳基、杂环基、酰基、磺酰基、烷氧羰基基团、氨基甲酰基基团、磺酰胺基基团、硫代酰基或硫代氨基甲酰基基团；R.sUP.3代表氢原子；R.sUP.2和R.sUP.3可以结合形成肼酮结构；L和R.sUP.1的一部分可以结合形成肼酮结构；n代表0或1。含有能够像图像地释放由一般式（I）所代表的雾化剂的化合物的银卤化物彩色摄影感光材料在保存期间具有较高的稳定性、对比度和灵敏度。还公开了使用该银卤化物彩色摄影感光材料形成彩色图像的方法。
• Silver halide color light-sensitive material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0118087A2

  公开（公告）日：1984-09-12

  A silver halide color light-sensitive material is described, which is increased in sensitivity, is adapted to form an image of high contrast, or is accelerated in development by incorporating a small amount of a specific compound which imagewise releases a foggant or a development accelerator. This compound is represented by the formula: Coup-(TIME)n-FA (wherein Coup represents a coupler radical capable of undergoing a coupling reaction with an oxidized product of an aromatic primary amine developing agent; TIME represents a timing group which is eliminated from Coup by the coupling reaction and, thereafter, releases FA; n is 0 or 1; and FA represents a group which is eliminated from Coup in the coupling reaction when n is 0, whereas FA is released from TIME when n is 1. The FA has adsorption properties with respect to silver halide grains and also has a substantial fogging action with respect to the silver halide grains).

  描述了一种卤化银彩色感光材料，通过加入少量特定的化合物，在图像上释放出雾剂或显影加速剂，从而提高感光度，形成高对比度的图像，或加速显影。这种化合物的化学式如下Coup-(TIME)n-FA （其中 Coup 代表能与芳香族伯胺显影剂的氧化产物发生偶联反应的偶联基；TIME 代表通过偶联反应从 Coup 中消除并随后释放出 FA 的定时基团；n 为 0 或 1；FA 代表当 n 为 0 时在偶联反应中从 Coup 中消除的基团，而当 n 为 1 时从 TIME 中释放出 FA。）