6-O-PO3H2-α-D-Man-(1->3)-α-D-Man-(1->3)-α-D-Man-(1->2)-D-Man

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-O-PO3H2-α-D-Man-(1->3)-α-D-Man-(1->3)-α-D-Man-(1->2)-D-Man
• 英文别名: Man6P(a1-3)Man(a1-3)Man(a1-2)Man；[(2R,3S,4S,5S,6R)-6-[(2R,3S,4S,5R,6R)-2-[(2R,3R,4S,5S,6R)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(3S,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl dihydrogen phosphate
• 化学式: C₂₄H₄₃O₂₄P
• 分子量: 746.565
• InChiKey: AQVRXHVRNIRNNX-SHOVVSDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9
• 重原子数：
  49
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  394
• 氢给体数：
  15
• 氢受体数：
  24

反应信息

• 作为反应物：
  描述：

  6-O-PO3H2-α-D-Man-(1->3)-α-D-Man-(1->3)-α-D-Man-(1->2)-D-Man 在 盐酸 、 potassium chloride 作用下， 以 水 为溶剂， 反应 7.0h， 以303 mg的产率得到α-D-Man-(1->3)-α-D-Man-(1->3)-α-D-Man-(1->2)-D-Man
  参考文献：
  名称：

  Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88

  摘要：

  Mild acid-catalysed hydrolysis of the extracellular phosphomannan of the yeast Pichia holstii NRRL Y-2448 produces a high-molecular-weight phosphomannan core, a low-molecular-weight oligosaccharide phosphate fraction, and a neutral oligosaccharide fraction. A method was developed for the large-scale preparation of the oligosaccharide phosphate fraction, consisting predominantly of the pentasaccharide phosphate, 6-O-PO3H2-alpha -D-Man-(1 --> 3)-alpha -D-Man-(1 --> 3)-alpha -D-Man-(1 --> 3)-alpha -D-Man-(1 --> 2)-D-Man, for use in the manufacture of the promising new anti-cancer agent, PI-88. Further insights were also gained into the structure of the phosphomannan by HPLC analysis of the time course of the hydrolysis reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0008-6215(01)00061-1

文献信息

• Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88
  作者：Vito Ferro、Kym Fewings、Maria C Palermo、Caiping Li

  DOI：10.1016/s0008-6215(01)00061-1

  日期：2001.5

  Mild acid-catalysed hydrolysis of the extracellular phosphomannan of the yeast Pichia holstii NRRL Y-2448 produces a high-molecular-weight phosphomannan core, a low-molecular-weight oligosaccharide phosphate fraction, and a neutral oligosaccharide fraction. A method was developed for the large-scale preparation of the oligosaccharide phosphate fraction, consisting predominantly of the pentasaccharide phosphate, 6-O-PO3H2-alpha -D-Man-(1 --> 3)-alpha -D-Man-(1 --> 3)-alpha -D-Man-(1 --> 3)-alpha -D-Man-(1 --> 2)-D-Man, for use in the manufacture of the promising new anti-cancer agent, PI-88. Further insights were also gained into the structure of the phosphomannan by HPLC analysis of the time course of the hydrolysis reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.