4-nitro-2-vinylaniline | 107734-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitro-2-vinylaniline
• 英文别名: 4-Nitro-2-vinylaniline；2-ethenyl-4-nitroaniline
• CAS: 107734-23-6
• 化学式: C₈H₈N₂O₂
• 分子量: 164.164
• InChiKey: PAVZFDKFGMSAAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-nitro-2-vinylaniline 在 sodium hydride 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.5h， 生成 2-iodo-N-methyl-N-(4-nitro-2-vinylphenyl)benzamide
  参考文献：
  名称：

  Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one Skeleton

  摘要：

  To obtain novel transrepression-selective liver X receptor (LXR) ligands, we adopted a strategy of reducing the transactivational agonistic activity of the 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one derivative 10, which exhibits LXR-mediated transrepressional and transactivational activity. Structural modification of 10 based on the reported X-ray crystal structure of the LXR ligand-binding domain led to a series of compounds, of which almost all exhibited transrepressional activity at 1 or 10 mu M but showed no transactivational activity even at 30 mu M. Among the compounds obtained, 18 and 22 were confirmed to have LXR-dependent transrepressional activity by using peritoneal macrophages from wild-type and LXR-null mice. A newly developed fluorescence polarization assay indicated that they bind directly to LXR alpha. Next, further structural modification was performed with the guidance of docking simulations with LXR alpha, focusing on enhancing the binding of the ligands with LXR alpha through the introduction of substituents or heteroatom(s). Among the compounds synthesized, compound 48, bearing a hydroxyl group, showed potent, selective, and dose-dependent transrepressional activity.

  DOI：

  10.1021/jm3002394
• 作为产物：
  描述：

  在 水 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 4-nitro-2-vinylaniline
  参考文献：
  名称：

  从2-乙烯基苯胺在腈溶剂中新型合成2-氯喹啉。

  摘要：

  使2-乙烯基-或杂芳基取代的苯胺与二光气在乙腈溶液中经由反应性亚胺基部分反应，得到相应的2-氯喹啉。描述了几种苯胺的九种2-氯喹啉衍生物的简便合成及其推定机理。通过亚氨基基团作为良好的离去基团形成2-氯喹啉的推测机理表明，该反应由以下三个步骤组成：（1）生成异氰酸苯酯；（2）喹啉环的形成；（3）在C2位的氯化喹啉。

  DOI：

  10.1021/jo016196i

文献信息

• Pd-^<i>t</i> BuONO Cocatalyzed Aerobic Indole Synthesis
  作者：Xiao-Shan Ning、Xin Liang、Kang-Fei Hu、Chuan-Zhi Yao、Jian-Ping Qu、Yan-Biao Kang

  DOI：10.1002/adsc.201701512

  日期：2018.4.17

  A Pd‐tBuONO co‐catalyzed scalable and practical synthesis of indoles with molecular oxygen as terminal oxidant is developed. Either terminal or internal 2‐vinylanilines could be smoothly converted to desired indoles under one general condition. This method has been evaluated in the large scale synthesis of indomethacin and a potential anti‐breast cancer drug candidate 1.

  甲的Pd-吨作为终端氧化剂被显影BUONO共催化的分子氧吲哚的可扩展性和实用的合成。在一种通用条件下，末端或内部2乙烯基苯胺均可顺利转化为所需的吲哚。吲哚美辛和潜在的抗乳腺癌候选药物1的大规模合成已对该方法进行了评估。
• Metal-free intramolecular amino-acyloxylation of 2-aminostyrene with carboxylic acid for the synthesis of 3-acyloxyl indolines in water
  作者：Liyan Liu、Zhiyong Wang

  DOI：10.1039/c7gc00212b

  日期：——

  A metal-free amino-acyloxylation of 2-aminostyrene was developed for the synthesis of 3-acyloxyl indolines.

  一种无金属的氨基酰氧化反应被开发用于合成3-酰氧基吲哚。
• Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6<i>H</i>-dibenz[<i>b</i>,<i>e</i>]azepin-6-one Skeleton
  作者：Atsushi Aoyama、Kaori Endo-Umeda、Kenji Kishida、Kenji Ohgane、Tomomi Noguchi-Yachide、Hiroshi Aoyama、Minoru Ishikawa、Hiroyuki Miyachi、Makoto Makishima、Yuichi Hashimoto

  DOI：10.1021/jm3002394

  日期：2012.9.13

  To obtain novel transrepression-selective liver X receptor (LXR) ligands, we adopted a strategy of reducing the transactivational agonistic activity of the 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one derivative 10, which exhibits LXR-mediated transrepressional and transactivational activity. Structural modification of 10 based on the reported X-ray crystal structure of the LXR ligand-binding domain led to a series of compounds, of which almost all exhibited transrepressional activity at 1 or 10 mu M but showed no transactivational activity even at 30 mu M. Among the compounds obtained, 18 and 22 were confirmed to have LXR-dependent transrepressional activity by using peritoneal macrophages from wild-type and LXR-null mice. A newly developed fluorescence polarization assay indicated that they bind directly to LXR alpha. Next, further structural modification was performed with the guidance of docking simulations with LXR alpha, focusing on enhancing the binding of the ligands with LXR alpha through the introduction of substituents or heteroatom(s). Among the compounds synthesized, compound 48, bearing a hydroxyl group, showed potent, selective, and dose-dependent transrepressional activity.
• Novel Synthesis of 2-Chloroquinolines from 2-Vinylanilines in Nitrile Solvent
  作者：Byoung Se Lee、Jae Hak Lee、Dae Yoon Chi

  DOI：10.1021/jo016196i

  日期：2002.11.1

  2-Vinyl- or heteroaryl-substituted anilines were reacted with diphosgene in acetonitrile solution via a reactive imidoyl moiety to afford the corresponding 2-chloroquinolines. Facile syntheses of nine 2-chloroquinoline derivatives from several anilines and their postulate mechanism is described. The postulate mechanism of 2-chloroquinoline formation via imidoyl moiety as a good leaving group shows

  使2-乙烯基-或杂芳基取代的苯胺与二光气在乙腈溶液中经由反应性亚胺基部分反应，得到相应的2-氯喹啉。描述了几种苯胺的九种2-氯喹啉衍生物的简便合成及其推定机理。通过亚氨基基团作为良好的离去基团形成2-氯喹啉的推测机理表明，该反应由以下三个步骤组成：（1）生成异氰酸苯酯；（2）喹啉环的形成；（3）在C2位的氯化喹啉。