docosan-2-one | 77327-11-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: docosan-2-one
• 英文别名: 2-Docosanone
• CAS: 77327-11-8
• 化学式: C₂₂H₄₄O
• 分子量: 324.591
• InChiKey: TWBHLKOHVHGYGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  docosan-2-one 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 docosan-2-ol
  参考文献：
  名称：

  Baykut; Oezeris, Istanbul Universitesi Fen Fakultesi Mecmuasi, Seri C: [Astronomi-Fizik-Kimya], 1957, vol. 22, p. 32,34,35

  摘要：

  DOI：
• 作为产物：
  描述：

  碘甲烷 在 锌铜偶 、 乙酸乙酯 、 甲苯 作用下， 生成 docosan-2-one
  参考文献：
  名称：

  Hospital-acquired infections among chronic hemodialysis patients

  摘要：

  The epidemiological characteristics of nosocomial infections among patients requiring chronic hemodialysis, a high-risk and rapidly growing population, have not been fully elucidated. During a 30 month cohort study, rates of bloodstream infections (BSIs), urinary tract infections (UTIs), pneumonia, and diarrhea caused by Clostridium difficile and the distribution of pathogens among hospitalized chronic hemodialysis patients were compared with hospitalized patients not requiring chronic hemodialysis, To identify risk factors for developing a nosocomial infection among chronic hemodialysis patients, a matched case-control study was performed. A total of 1,557 nosocomial infections were detected during 1,317 of 68,361 admissions (2%). Of these, 47 nosocomial infections occurred in chronic hemodialysis patients during 31 of 578 admissions (5%). Nosocomial infections were significantly more frequent among the chronic hemodialysis group (9.1/1,000 patient-days) compared with the non-chronic hemodialysis group (3.8/1,000 patient-days; relative risk [RR], 2.4; 95% confidence interval [CI], 1.8 to 3.2; P < 0.001). UTIs were the most common nosocomial infections among chronic hemodialysis patients, accounting for 47% of all infections in this population. UTIs were significantly more common among chronic hemodialysis patients (4.2/1,000 patient-days) compared with non-chronic hemodialysis patients (0.7/1,000 patient-days; RR, 6.2; 95% CI, 3.8 to 9.5; P < 0.001). Among chronic hemodialysis patients, Candida spp and enterococci were the most common pathogens in contrast to coagulase-negative staphylococci and Staphylococcus aureus among patients not requiring hemodialysis. Using conditional logistic regression, a greater index of comorbidity was significantly associated with nosocomial infections among the chronic hemodialysis population (odds ratio, 3.6; 95% CI, 1.2 to 10.7; P = 0.02), Chronic hemodialysis patients are at a substantially greater risk for developing a nosocomial infection compared with other hospitalized patients. (C) 2000 by the National Kidney Foundation, Inc.

  DOI：

  10.1016/s0272-6386(00)70044-8

文献信息

• Glycerin derivatives and process for producing the same
  申请人：KAO CORPORATION

  公开号：EP0624563A1

  公开（公告）日：1994-11-17

  Glycerine derivatives represented by formula (1A), (2A) and (3A): wherein R1a, R2a, R1b, R2b, R1c, and R2c are as defined in the disclosure, and process for producing glycerin derivatives, including the glycerin derivatives (1A), (2A) and (3A), are disclosed. The glycerin derivatives have satisfactory physical properties and are applicable as lubricants or polar oils and also have mutual effects with water and are applicable as emulsifying agents or moisture retaining agents. The process makes it possible to synthesize glycerin derivatives from easily and economically available aldehydes or ketones in high yields.

  公式（1A）、（2A）和（3A）代表的甘油衍生物：其中R1a、R2a、R1b、R2b、R1c和R2c如披露中所定义，并公开了生产甘油衍生物的方法，包括甘油衍生物（1A）、（2A）和（3A）。这些甘油衍生物具有令人满意的物理性质，可用作润滑剂或极性油，并且与水有相互作用，可用作乳化剂或保湿剂。该方法使得可以从易于获得且经济可行的醛类或酮类高产率地合成甘油衍生物。
• Triglycerides containing saturated fatty acids having 20 to 24 carbon atoms useful in lowering blood cholesterol levels
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0422490A2

  公开（公告）日：1991-04-17

  Triglyceride fats based on very long chain C₂₀ to C₂₄ saturated fatty acid triglycerides that are effective in lowering blood cholesterol levels are disclosed. These triglyceride fats are useful in pharmaceutical compositions in effective unit dosage amounts for inhibiting cholesterol absorption and in methods for treating hypercholesterolemia. These triglyceride fats are also useful, in whole or in part, in the triglyceride fat component of fat-containing food compositions. These fat-containing food compositions can be used as part of a dietary method or regimen for lowering blood cholesterol levels.

  本发明公开了可有效降低血液胆固醇水平的基于超长链 C₂₀ 至 C₂₄ 饱和脂肪酸甘油三酯的甘油三酯脂肪。这些甘油三酯脂肪可用于有效单位剂量的药物组合物，以抑制胆固醇的吸收，并用于治疗高胆固醇血症的方法。这些甘油三酯脂肪还可全部或部分用于含脂肪食品组合物中的甘油三酯脂肪成分。这些含脂食品组合物可用作降低血液胆固醇水平的饮食方法或方案的一部分。
• Thermochromic microencapsulated pigments
  申请人：THE PILOT INK CO., LTD.

  公开号：EP1084860A2

  公开（公告）日：2001-03-21

  Disclosed is a thermochromic microencapsulated pigment which comprises as four essential components (a) an electron-donating chromatic organic compound, (b) an electron-accepting compound, (c) a reaction medium determining the temperatures at which the color reactions of component (a) with component (b) take place, and (d) a color change temperature regulator, the color change temperature regulator (d) comprising one or more compounds selected from the group consisting of esters, alcohols, ketones, acid amides, hydrocarbons, and fatty acids and having a melting point Y (°C) satisfying the relationship (X+30)°C≤Y≤200°C, wherein X (°C) is the melting point of component (c), and the four essential components being microencapsulated.

  本发明公开了一种热致变色微胶囊颜料，它由四种基本成分组成：(a) 一种电子供色有机化合物；(b) 一种电子受色化合物；(c) 一种决定成分(a)与成分(b)发生颜色反应的温度的反应介质；(d) 一种变色温度调节剂、变色温度调节剂(d)包括一种或多种从酯、醇、酮、酸酰胺、烃和脂肪酸组成的组中选出的化合物，其熔点 Y(℃)满足(X+30)℃≤Y≤200℃的关系，其中 X(℃)是组分(c)的熔点，四种基本组分被微胶囊化。
• Irreversible heat-sensitive composition
  申请人：Nichiyu Giken Kogyo Co., Ltd.

  公开号：EP1149880A1

  公开（公告）日：2001-10-31

  An irreversible heat-sensitive composition comprises a mixture of a granular or powdery heat-fusible substance having a melting point corresponding to a temperature to be recorded and a granular or powdery dyestuff diffusible into the fused heat-fusible substance through dispersion or dissolution. A heat-sensitive ink comprises the irreversible heat-sensitive composition and an ink vehicle capable of diffusing the fused heat-fusible substance therein. A heat-sensitive ink according to another embodiment comprises microcapsules, which encapsulate the irreversible heat-sensitive composition. A heat-sensitive indicator comprises a substrate provided thereon with a printed heat-sensitive ink, the heat-sensitive ink being one of these heat-sensitive inks.

  不可逆热敏组合物包括熔点与待记录温度相对应的颗粒状或粉状热敏物质与可通过分散或溶解扩散到熔融热敏物质中的颗粒状或粉状染料的混合物。热敏油墨包括不可逆热敏组合物和能够将熔融热敏物质扩散到其中的油墨载体。根据另一个实施方案，热敏油墨包括封装不可逆热敏组合物的微胶囊。热敏指示器包括一个基板，基板上印有热敏油墨，热敏油墨是这些热敏油墨中的一种。
• WRITING IMPLEMENT AND WRITING IMPLEMENT SET
  申请人：THE PILOT INK CO., LTD.

  公开号：EP2072277A1

  公开（公告）日：2009-06-24

  Provided are a writing instrument produced at a lower cost than conventional thermochromic writing instruments utilizing frictional heat, slim like a pencil and not bulky because it contains an ink directly in a barrel thereof, and excellent in portability; and a set of the writing instruments. The writing instrument 1 is obtained by directly filling a barrel thereof with an ink 2 which becomes colorless or colored, or undergoes a color change by heating and an ink follower 5 following the ink with its consumption; firmly fixing a writing tip portion 3 to the end of the barrel directly or via a relay member; and disposing a friction body 6 having an elasticity at the rear end portion of the barrel. The writing instrument set has a plurality of the writing instruments respectively different from each other in color tone.

  本发明提供了一种书写工具，与传统的利用摩擦热的热致变色书写工具相比，其生产成本更低；该书写工具像铅笔一样纤细，由于直接在其笔管中装有墨水而不笨重，并且便携性极佳；还提供了一套该书写工具。 书写工具 1 是通过以下方式获得的：在其笔管中直接注入墨水 2，墨水 2 通过加热变为无色或有色，或发生颜色变化，墨水跟随器 5 随着墨水的消耗而变化；将书写尖端部分 3 直接或通过中继部件牢固地固定在笔管的末端；以及在笔管的后端部分配置具有弹性的摩擦体 6。这套书写工具具有多个色调各不相同的书写工具。

表征谱图