苯丙酸,2-溴-b-甲基-,乙基酯 | 174702-74-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 苯丙酸,2-溴-b-甲基-,乙基酯
• 英文名称: 3-(2-Bromo-phenyl)-butyric acid ethyl ester
• 英文别名: Ethyl 3-(2-bromophenyl)-3-methylpropionate；ethyl 3-(2-bromophenyl)butanoate
• CAS: 174702-74-0
• 化学式: C₁₂H₁₅BrO₂
• 分子量: 271.154
• InChiKey: LINPQERFBQJRGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯丙酸,2-溴-b-甲基-,乙基酯 在 lithium hydroxide 、 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 乙二醇二甲醚 为溶剂， 生成 3-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl}-butyric acid
  参考文献：
  名称：

  Structure–activity relationship of triaryl propionic acid analogues on the human EP 3 prostanoid receptor

  摘要：

  Potent and selective ligands for the human EP3 prostanoid receptor are described. Triaryl compounds bearing an ortho-substituted propionic acid moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinities of key compound on all eight human prostanoid receptors is reported. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00794-7
• 作为产物：
  描述：

  ethyl (E)-3-(2-bromophenyl)but-2-enoate 在 苯磺酰肼 作用下， 以 甲苯 为溶剂， 生成 苯丙酸,2-溴-b-甲基-,乙基酯
  参考文献：
  名称：

  Structure–activity relationship of triaryl propionic acid analogues on the human EP 3 prostanoid receptor

  摘要：

  Potent and selective ligands for the human EP3 prostanoid receptor are described. Triaryl compounds bearing an ortho-substituted propionic acid moiety were identified as potent EP3 antagonists based on the SAR described herein. The binding affinities of key compound on all eight human prostanoid receptors is reported. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00794-7

文献信息

• Catalyst component for the polymerization of .alpha.-olefins and a
  申请人：Mitsubishi Chemical Corporation

  公开号：US05594081A1

  公开（公告）日：1997-01-14

  The present invention provides a catalyst for polymerizing an .alpha.-olefin which is capable of producing an .alpha.-olefin polymer having a high molecular weight in a high yield under the polymerization conditions including at high temperature, and a process for preparing an .alpha.-olefin polymer, which catalyst comprises a Component (A) which comprises a coordination compound having a skeleton of a metallocene compound comprising an indenyl ring or a hydroindenyl ring which is an indenyl having a six-membered portion hydrogenated as a ligand and having Ti, Zr or Hf as a metal component in combination with a Component (B) which is, for example, an alumoxane. The coordination compound is crosslinked at the six-membered rings characterized by the fact that two of the indenyl or hydroindenyl groups are crosslinked at the six-membered ring of the indenyl or hydroindenyl group.

  本发明提供了一种催化剂，用于聚合能够在高温条件下产生高分子量α-烯烃聚合物的α-烯烃，并且在聚合条件下高产率，以及一种制备α-烯烃聚合物的方法，该催化剂包括组分（A），其包括具有金属茂化合物骨架的配位化合物，该金属茂化合物包括一个具有六元环部分氢化的茚基环或氢茚基环的茂基环作为配体，并且具有Ti、Zr或Hf作为金属组分，与组分（B），例如铝氧烷，结合使用。该配位化合物在六元环上交联，其特征在于两个茚基或氢茚基组分在茚基或氢茚基组分的六元环上交联。
• Catalysts for olefin polymerization and a process for preparing olefin
  申请人：Mitsubishi Chemical Corporation

  公开号：US05942459A1

  公开（公告）日：1999-08-24

  The object of the present invention is to provide a polyolefin having a good particle property in a high yield without use of an expensive alumoxane. The present invention comprises a catalyst for olefin polymerization comprising the following ingredients (A), (B) and (C), and a process for preparing an olefin polymer with use of the catalyst: Component (A): a transition metal compound having at least one conjugated five-membered ring ligand, the transition metal being in the Groups IV-VI of the Periodic Table, Component (B): an organoaluminum compound, and Component (C): a finely divided particle composition comprising 0.1-99.9% by weight of boric acid.

  本发明的目的是提供一种聚烯烃，其具有良好的颗粒特性，且不需要使用昂贵的氧化铝。本发明包括用于烯烃聚合的催化剂，该催化剂包括以下成分（A）、（B）和（C），以及使用该催化剂制备烯烃聚合物的方法：组分（A）：至少具有一个共轭五元环配体的过渡金属化合物，该过渡金属位于周期表的IV-VI族，组分（B）：有机铝化合物，以及组分（C）：包含0.1-99.9重量％硼酸的细粉末组成。
• Catalyst component for the polymerization of alpha-olefins and a process for preparing alpha-olefin polymers with use of same
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0693502A1

  公开（公告）日：1996-01-24

  The present invention provides a catalyst for polymerizing an α-olefin which is capable of producing an α-olefin polymer having a high molecular weight in a high yield under the polymerization conditions including at high temperature, and a process for preparing an α-olefin polymer, which catalyst comprises a Component (A) represented by the formulae (Ia) or (Ib) in which M is Ti, Zr or Hf in combination with a Component (B) which is, for example, an alumoxane.

  本发明提供了一种用于α-烯烃聚合的催化剂，该催化剂能够在包括高温在内的聚合条件下以高产率生产具有高分子量的α-烯烃聚合物，本发明还提供了一种制备α-烯烃聚合物的工艺，该催化剂包括由式(Ia)或(Ib)表示的组分(A)，其中M为Ti、Zr或Hf。 与组分 (B) 结合使用，组分 (B) 例如铝氧烷。
• Catalysts for olefin polymerization and a process for preparing olefin polymers therewith
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0728773B1

  公开（公告）日：1998-11-04
• US5594081A
  申请人：——

  公开号：US5594081A

  公开（公告）日：1997-01-14