1-Acetamino-3-dimethylamino-propanol-(2) | 89850-77-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Acetamino-3-dimethylamino-propanol-(2)
• 英文别名: N-[3-(dimethylamino)-2-hydroxypropyl]acetamide
• CAS: 89850-77-1
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.216
• InChiKey: IAODMQJRJQBQSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Phthalimido-3-dimethylamino-propanol-(2) 、 乙酸酐 生成 1-Acetamino-3-dimethylamino-propanol-(2)
  参考文献：
  名称：

  拟胆碱和胆碱解活性的化学基础研究：第 I 部分 1,3-二氧戊环和恶唑啉系列季盐的合成和构型

  摘要：

  简要讨论了毒蕈碱和四元 1,3-二氧戊环（Fourneau 系列）系列中的构效关系。后者系列中最活跃的成员（2-甲基-4-二甲基氨基甲基-1,3-二氧戊环甲硫醚，（IX），F2268）显示由 60% 顺式和 40% 反式异构体的混合物组成。发现同样适用于该系列中的所有合成中间体。通过将导致 (IX) 及其类似物的各种中间体与 D-cis-1,3-二甲基-1,3-二氧戊环本身相关联，通过降解 1,6-脱水半乳糖获得明确的构型分配。尝试分离 1,3-二氧戊环系列中的顺反异构体没有成功。然而，顺式，反式-2-三氯甲基-4-羟甲基-1,3-二氧戊环 (XVI) 的混合物可以通过相应甲苯磺酸盐的结晶进行分馏。

  DOI：

  10.1139/v62-183

文献信息

• Subterranean Reservoir Treatment Method
  申请人：SCHLUMBERGER TECHNOLOGY CORPORATION

  公开号：US20160040059A1

  公开（公告）日：2016-02-11

  A method is given for heterogeneous proppant placement in fracturing by in situ aggregation of fine mesh proppant particulates or other materials such as fibers in a subterranean fracture. A polymer is injected into a subterranean formation and is subsequently subjected to a chemical reaction, for example hydrolysis, under downhole conditions, which leads to formation of either a cationic or an anionic polyelectrolyte. Alternatively, the polyelectrolyte is synthesized downhole by, for example, a Hofmann degradation or a Mannich reaction. The polyelectrolyte acts as a flocculant and provides aggregation of solid particulates such as sand, mica, silica flour, ceramics and the like, which leads to formation of proppant micropillars deep in the fracture. Methods of aggregation of fibers to enhance bridging, and other applications of controlled flocculation are also given.
• [EN] PRMT5 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014100719A2

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5 mediated disorders are also described.
• [EN] METHODS OF INHIBITING PRMT5<br/>[FR] PROCÉDÉS D'INHIBITION DE PRMT5
  申请人：EPIZYME INC

  公开号：WO2014100764A2

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (I) useful for inhibiting PRMT5 activity. The planes of Ring AA and Ring BB are between 75° and 105°. Ring AA-M-Ring BB (I)
• [EN] TLR7/8 ANTAGONISTS AND USES THEREOF<br/>[FR] ANTAGONISTES DE TLR7/8 ET LEURS UTILISATIONS
  申请人：MERCK PATENT GMBH

  公开号：WO2020025517A1

  公开（公告）日：2020-02-06

  The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists.
• STUDIES ON THE CHEMICAL BASIS FOR CHOLINOMIMETIC AND CHOLINOLYTIC ACTIVITY: PART I. THE SYNTHESIS AND CONFIGURATION OF QUATERNARY SALTS IN THE 1,3-DIOXOLANE AND OXAZOLINE SERIES
  作者：D. J. Triggle、B. Belleau

  DOI：10.1139/v62-183

  日期：1962.6.1

  muscarine and the quaternary 1,3-dioxolane (Fourneau series) series are briefly discussed. The most active member of the latter series (2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide, (IX), F2268) was shown to consist of a mixture of 60% cis and 40% trans isomers. The same was found to apply to all synthetic intermediates in that series. Unequivocal assignments of configuration were made by

  简要讨论了毒蕈碱和四元 1,3-二氧戊环（Fourneau 系列）系列中的构效关系。后者系列中最活跃的成员（2-甲基-4-二甲基氨基甲基-1,3-二氧戊环甲硫醚，（IX），F2268）显示由 60% 顺式和 40% 反式异构体的混合物组成。发现同样适用于该系列中的所有合成中间体。通过将导致 (IX) 及其类似物的各种中间体与 D-cis-1,3-二甲基-1,3-二氧戊环本身相关联，通过降解 1,6-脱水半乳糖获得明确的构型分配。尝试分离 1,3-二氧戊环系列中的顺反异构体没有成功。然而，顺式，反式-2-三氯甲基-4-羟甲基-1,3-二氧戊环 (XVI) 的混合物可以通过相应甲苯磺酸盐的结晶进行分馏。