(2R,4R)-4-amino-5-(5'-chloro-2'-fluoro-biphenyl-4-yl)-2-hydroxypentanoic acid ethyl ester hydrochloride 、
sodium 5-methyloxazole-2-carboxylate 在
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、
N,N-二异丙基乙胺 作用下,
以
N,N-二甲基甲酰胺 为溶剂,
反应 2.0h,
生成 ethyl (2R,4R)-5-[4-(5-chloro-2-fluorophenyl)phenyl]-2-hydroxy-4-[(5-methyl-1,3-oxazole-2-carbonyl)amino]pentanoate