2,3-dimethyl-3-(methylamino)-2-butanol | 113181-26-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dimethyl-3-(methylamino)-2-butanol
• 英文别名: 2,3-dimethyl-3-(methylamino)butan-2-ol
• CAS: 113181-26-3
• 化学式: C₇H₁₇NO
• 分子量: 131.218
• InChiKey: OVQUYKYRAZNDGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dimethyl-3-(methylamino)-2-butanol 在 溴 、 三乙胺 、 三苯基膦 作用下， 生成 1,2,2,3,3-pentamethylaziridine
  参考文献：
  名称：

  Ring-opening reactions. 5. Elimination vs substitution in the cleavage of 1,1,2,2,3,3-hexamethylaziridinium ion

  摘要：

  DOI：

  10.1021/jo00243a025

文献信息

• Transfer Hydrogenation of Cyclopamine Analogs
  申请人：Genov Daniel G.

  公开号：US20120065399A1

  公开（公告）日：2012-03-15

  Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.

  本文提供了一种用于将似jervine型Veratrum生物碱的酮类似物（如环毒素）进行转移氢化的方法。本文还提供了新型的钌转移氢化催化剂。
• TRANSFER HYDROGENATION OF CYCLOPAMINE ANALOGS
  申请人：Infinity Pharmaceuticals, Inc.

  公开号：US20170029433A1

  公开（公告）日：2017-02-02

  Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.

  本文提供了一种将拟麻酮类似物，如环状毒草碱转移氢化的方法，例如环状毒草碱。本文还提供了新型的钌催化剂用于转移氢化反应。
• CHIRAL CONTROL
  申请人：WAVE LIFE SCIENCES PTE. LTD.

  公开号：US20150211006A1

  公开（公告）日：2015-07-30

  The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

  本发明涉及手性控制的寡核苷酸、手性控制的寡核苷酸组合物以及其制备和使用方法。本发明特别涵盖了鉴定以前制备手性寡核苷酸方法中某些问题的来源，包括禁止制备完全手性控制的组合物，特别是包含多种寡核苷酸类型的组合物。在某些实施例中，本发明提供了手性控制的寡核苷酸组合物。在某些实施例中，本发明提供了制备手性控制的寡核苷酸和手性控制的寡核苷酸组合物的方法。
• Multifunctional primary amine, process for its preparation, and use thereof
  申请人：Allnex AUSTRIA GmbH

  公开号：US10023547B2

  公开（公告）日：2018-07-17

  The invention relates to a hydrophilically modified multifunctional amine AC which has more than one primary amino group per molecule, and at least one group per molecule derived from the reaction of an epoxide group with a reactive group selected from the group consisting of secondary amino groups >NH, hydroxyl groups —OH, mercaptan groups —SH, amide groups —CO—NHR, where R can be hydrogen or an alkyl group having from one to twelve carbon atoms, hydroxyester groups, and acid groups, particularly carboxyl groups —COOH, sulphonic acid groups —SO3H, and phosphonic acid groups —PO3H2, and preferably, also moieties which are compatible with an epoxy resin, as well as a process for its preparation, and a method of use thereof.

  本发明涉及一种亲水改性的多功能胺 AC，其每个分子具有一个以上的伯氨基， 以及至少一个由环氧基团与反应基团反应衍生的基团，反应基团选自由仲氨基 >NH、羟基 -OH、硫醇基 -SH、酰胺基 -CO-NHR、其中，R 可以是氢或具有 1 至 12 个碳原子的烷基、羟酯基团和酸基团，特别是羧基 -COOH、磺酸基团 -SO3H 和膦酸基团 -PO3H2，最好还包括与环氧树脂相容的分子，以及其制备工艺和使用方法。
• Method for preventing hardener compounds to be formed from hardener precursors and extending shelf life of the dispersion
  申请人：Wisespray International Ltd

  公开号：US11028274B2

  公开（公告）日：2021-06-08

  A method is disclosed for preventing hardener compounds to be formed from hardener precursors in a sealed and pressurized aerosol can. This includes a paint forming dispersion containing after sealing the can a liquefied propellant, epoxy or/and polyurethane resins amount W1, hardener precursor of the epoxy or/and polyurethane resins amount W3, where the epoxy or urethane hardener precursors are selected from a group including an imine, an enamine, a Mannich base, a Schiff's base, an oxazolidine, an aldimine and mixtures thereof, free water of amount W1 in a range of 1-10000 ppm, and brought into the can alongside with the other paint dispersion forming chemicals before sealing the can. A catalytic compound prevents formation of the epoxy or/and polyurethane hardener amines from the epoxy or/and polyurethane hardener precursors:

  本发明公开了一种防止固化剂前体在密封加压气雾罐中形成固化剂化合物的方法。该方法包括一种涂料成型分散体，该分散体在封罐后含有液化推进剂、环氧树脂或/和聚氨酯树脂量 W1、环氧树脂或/和聚氨酯树脂的固化剂前体量 W3，其中环氧树脂或聚氨酯固化剂前体选自包括亚胺、烯胺、曼尼希碱、席夫碱在内的一组、烯胺、曼尼希碱、席夫碱、噁唑烷、醛亚胺及其混合物，游离水量 W1 在 1-10000 ppm 范围内，并在封罐前与其他涂料分散剂一起带入罐中。催化化合物可防止环氧或/和聚氨酯固化剂前体形成环氧或/和聚氨酯固化剂胺：