methyl-4 nonen-3(Z) one-2 | 107647-45-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl-4 nonen-3(Z) one-2
• 英文别名: (Z)-4-methylnon-3-en-2-one
• CAS: 107647-45-0
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: FGBGCGFTHADDBB-HJWRWDBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-Methylthio-3-methyl-3-buten-1-yne 在 水 、 mercury dichloride 作用下， 以 乙腈 为溶剂， 反应 65.5h， 生成 methyl-4 nonen-3(Z) one-2
  参考文献：
  名称：

  Guittet, Eric; Bibang Bi Ekogha, Cyriaque; Julia, Sylvestre A., Bulletin de la Societe Chimique de France, 1986, # 2, p. 325 - 331

  摘要：

  DOI：

文献信息

• Novel Dihydroxybenzene Derivatives and Antiprotozoal Agent Comprising Same as Active Ingredient
  申请人：Saimoto Hiroyuki

  公开号：US20130296422A1

  公开（公告）日：2013-11-07

  Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R 1 represents a hydrogen atom; R 2 represents a hydrogen atom or a C 1-7 alkyl group; R 3 represents —CHO, —C(═O)R 5 , —COOR 5 (wherein R 5 represents a C 1-7 alkyl group), —CH 2 OH or —COOH; and R 4 represents a C 1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C 2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C 2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.

  以下新化合物对于预防或治疗由原虫引起的疾病是有用的。其中至少一种由公式（I）表示的化合物（其中，X表示氢原子或卤素原子；R1表示氢原子；R2表示氢原子或C1-7烷基；R3表示—CHO，—C（═O）R5，—COOR5（其中R5表示C1-7烷基），—CH2OH或—COOH；R4表示具有一个或多个取代基的C1-16烷基，在末端碳原子和/或非末端碳原子上，具有一个或多个取代基的C2-16烯基，或者具有一个或多个取代基的C2-16炔基），其光学异构体和药学上可接受的盐被使用。
• DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR
  申请人：NAI INC.

  公开号：US20150166498A1

  公开（公告）日：2015-06-18

  The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R 1 represents a hydrogen atom, R 2 represents an alkyl group containing 1 to 7 carbon atoms, R 3 represents —CHO, and R 4 represents —CH 2 —CH═C(CH 3 )—R 0 (wherein R 0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti- H. pylori agent, a therapeutic agent for diabetes or the like.

  本发明提供了一种新型的二氢乳酸酸脱氢酶抑制剂，可用于多种疾病。当用作活性成分时，式（I）所表示的化合物：（其中X表示卤素原子，R1表示氢原子，R2表示含有1至7个碳原子的烷基，R3表示—CHO，R4表示—CH2—CH═C(CH3)—R0（其中R0表示含有1至12个碳原子的烷基，其末端碳和/或非末端碳上可能有取代基等），其光学异构体或其药学上可接受的盐对二氢乳酸酸脱氢酶具有高抑制作用，可用作免疫抑制剂、治疗风湿病的药物、抗癌药物、移植排斥治疗药物、抗病毒药物、抗H. pylori药物、糖尿病治疗药物或类似药物。
• GUITTET, E.;BIBANG, BI, EKOGHA, C.;JULIA, S. A., BULL. SOC. CHIM. FR., 1986, N 2, 325-331
  作者：GUITTET, E.、BIBANG, BI, EKOGHA, C.、JULIA, S. A.

  DOI：——

  日期：——
• SUBSTITUIERTE 5-(CYCLOHEX-2-EN-1-YL)-PENTA-2,4-DIENE UND 5-(CYCLOHEX-2-EN-1-YL)-PENT-2-EN-4-INE ALS WIRKSTOFFE GEGEN ABIOTISCHEN PFLANZENSTRESS
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2697193B1

  公开（公告）日：2016-07-06
• DIHYDROOROTIC AND ACID DEHYDROGENASE INHIBITOR
  申请人：NAI INC.

  公开号：US20160296494A1

  公开（公告）日：2016-10-13

  The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R 1 represents a hydrogen atom, R 2 represents an alkyl group containing 1 to 7 carbon atoms, R 3 represents —CHO, and R 4 represents —CH 2 —CH═C(CH 3 )—R 0 (wherein R 0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti- H. pylori agent, a therapeutic agent for diabetes or the like.