[3,4,5-Triacetyloxy-6-(3,4-dimethylphenoxy)oxan-2-yl]methyl acetate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [3,4,5-Triacetyloxy-6-(3,4-dimethylphenoxy)oxan-2-yl]methyl acetate
• 化学式: C₂₂H₂₈O₁₀
• 分子量: 452.5
• InChiKey: IOOHVVLXBLLRMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• TNF SUPERFAMILY TRIMERIZATION INHIBITORS
  申请人：B.S.R.C. "Alexander Fleming"

  公开号：US20140165223A1

  公开（公告）日：2014-06-12

  Described are methods and compositions for inhibiting the trimerization of ligands belonging to the TNF superfamily, in particular, inhibiting RANKL trimerization. Accordingly, the methods and compositions provided herein can be used to treat disorders associated with increased RANK signaling, in particular those related to bone loss. Compounds that inhibit trimerization of ligands belonging to the TNF superfamily are also described.