Usaf D-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Usaf D-8
• 英文别名: [3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]thiourea
• 化学式: C₇H₁₄N₂O₅S
• 分子量: 238.26
• InChiKey: NFLXFOWCDDYFIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  160
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Novel multicyclic compounds and the use thereof
  申请人：——

  公开号：US20020028815A1

  公开（公告）日：2002-03-07

  The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

  本发明涉及介导酶活性的新型多环分子。具体而言，这些化合物可能在治疗与PARP、VEGFR2和MLK3酶活性相关的疾病或疾病状态方面具有有效性，例如神经退行性疾病、炎症、缺血和癌症。
• NOVEL MULTICYCLIC COMPOUNDS AND THE USE THEREOF
  申请人：Chatterjee Sankar

  公开号：US20110059959A1

  公开（公告）日：2011-03-10

  The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

  本发明涉及新型多环分子，可介导酶活性。特别是，这些化合物可以在治疗与PARP、VEGFR2和MLK3酶活性相关的疾病或疾病状态方面发挥作用，包括例如神经退行性疾病、炎症、缺血和癌症。
• Multicyclic compounds and their use as inhibitors of PARP, VEGFR2 and MLK3 enzymes
  申请人：CEPHALON, INC.

  公开号：EP1754707A2

  公开（公告）日：2007-02-21

  The present invention is directed to novel multicyclic molecules of formula Ia that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

  本发明涉及介导酶活性的式 Ia 的新型多环分子。特别是，这些化合物可有效治疗与 PARP、VEGFR2 和 MLK3 酶活性有关的疾病或疾病状态，例如包括神经退行性疾病、炎症、缺血和癌症。
• MULTICYCLIC COMPOUNDS AND THE USE THEREOF AS INHIBITORS OF PARP, VEGFR2 AND MLK3 ENZYMES
  申请人：CEPHALON, INC.

  公开号：EP1294725A2

  公开（公告）日：2003-03-26
• MULTICYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PARP, VEGFR2 AND MLK3 ENZYMES
  申请人：CEPHALON, INC.

  公开号：EP1294725B1

  公开（公告）日：2006-01-04