benzyl N-[2-[tert-butyl(dimethyl)silyl]oxyhexyl]-N-(phenylmethoxycarbonylamino)carbamate | 163804-26-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl N-[2-[tert-butyl(dimethyl)silyl]oxyhexyl]-N-(phenylmethoxycarbonylamino)carbamate
• CAS: 163804-26-0
• 化学式: C₂₈H₄₂N₂O₅Si
• 分子量: 514.737
• InChiKey: REJNVLVRQAUJFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.05
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  benzyl N-[2-[tert-butyl(dimethyl)silyl]oxyhexyl]-N-(phenylmethoxycarbonylamino)carbamate 在 4-二甲氨基吡啶 、 palladium on activated charcoal 盐酸 、 正丁基锂 、 硫酸 、 氢气 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 吡啶 、 甲醇 、 六甲基磷酰三胺 、 乙醇 、 溶剂黄146 为溶剂， 反应 27.0h， 生成 [(2R,3S)-3-[2-(2-hydroxyhexyl)hydrazinyl]butan-2-yl] acetate
  参考文献：
  名称：

  Regioselective oxidation of β-hydroxyazo compounds to β-hydroxyazoxy compounds and its application to syntheses of maniwamycins A and B

  摘要：

  A new preparation of beta-hydroxyazo compounds and regioselectivities on their oxidation to beta-hydroxyazoxy compounds have been described. A new synthesis of antifungal antibiotic maniwamycin A and the first synthesis of maniwamycin B by using this methodology have been also described.

  DOI：

  10.1016/s0040-4039(00)61737-9
• 作为产物：
  描述：

  benzyl N-(2-oxohexyl)-N-(phenylmethoxycarbonylamino)carbamate 在 sodium tetrahydroborate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 1.17h， 生成 benzyl N-[2-[tert-butyl(dimethyl)silyl]oxyhexyl]-N-(phenylmethoxycarbonylamino)carbamate
  参考文献：
  名称：

  Regioselective oxidation of β-hydroxyazo compounds to β-hydroxyazoxy compounds and its application to syntheses of maniwamycins A and B

  摘要：

  A new preparation of beta-hydroxyazo compounds and regioselectivities on their oxidation to beta-hydroxyazoxy compounds have been described. A new synthesis of antifungal antibiotic maniwamycin A and the first synthesis of maniwamycin B by using this methodology have been also described.

  DOI：

  10.1016/s0040-4039(00)61737-9

文献信息

• Regioselective oxidation of β-hydroxyazo compounds to β-hydroxyazoxy compounds and its application to syntheses of maniwamycins A and B
  作者：Masaya Nakata、Soichiro Kawazoe、Tetsuro Tamai、Kuniaki Tatsuta、Hiroyuki Ishiwata、Yoshio Takahashi、Yukihiro Okuno、Takeo Deushi

  DOI：10.1016/s0040-4039(00)61737-9

  日期：1993.9

  A new preparation of beta-hydroxyazo compounds and regioselectivities on their oxidation to beta-hydroxyazoxy compounds have been described. A new synthesis of antifungal antibiotic maniwamycin A and the first synthesis of maniwamycin B by using this methodology have been also described.