7H-嘌呤-6,7-二胺 | 175600-97-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 7H-嘌呤-6,7-二胺
• 英文名称: 7-aminoadenine
• 英文别名: 7H-Purine-6,7-diamine；purine-6,7-diamine
• CAS: 175600-97-2
• 化学式: C₅H₆N₆
• 分子量: 150.143
• InChiKey: UDPYVYQYYOZYJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7H-嘌呤-6,7-二胺 在 disodium hydrogenphosphate 、 potassium dihydrogenphosphate 、 重水 作用下， 生成
  参考文献：
  名称：

  Substituent Effect of an N-Amino Group on the H-D Exchange of Ring Hydrogens of Adenines Compared with an N-Methyl Group

  摘要：

  DOI：

  10.3987/com-96-7656
• 作为产物：
  描述：

  3-pivaloyloxymethyladenine 在 ammonium hydroxide 、 dinitrophenoxyamine 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 7H-嘌呤-6,7-二胺
  参考文献：
  名称：

  Electrophilic Amination of Adenines. Formation and Characteristics ofN-Aminoadenines

  摘要：

  Amination of adenine with H2N-O-SO3H in alkaline media afforded 1-, 3-, 7- and 9-aminoadenine isomers at a ratio of about 1:1:3:1. In neutral media, the product ratio of the isomers changed to about 3:1:1:0. These results were different from the regioselectivity obtained by methylation of adenine with dimethyl sulfate under similar conditions. Amination of adenine with dinitrophenoxyamine in DMF gave 1-aminoadenine as the main product and this regioselectivity was also different from that of methylation with CH.3I. Chemical characteristics of these N-amino adenines are described.

  DOI：

  10.1080/07328319608002381

文献信息

• Reactions of 7- and 9-aminoadenines with 2,4-pentanedione. Formation of new ring systems, pyridazino[6,1-f]purine and pyridazino[1,6-e]purine
  作者：Toyo Kaiya、Tetsuya Saga、Yuriko Yamagata、Kohfuku Kohda

  DOI：10.1016/s0960-894x(98)00392-8

  日期：1998.8

  Reactions of 7-aminoadenines with 2,4-pentanedione yielded pyridazino[6,1-f]purines and 5-pyrazolylpyrimidines. The structure of the latter was identified by X-ray analysis. Reaction of 9-amino-N6-methyladenine with 2,4-pentanedione gave pyridazino[1,6-e]purine and Schiff base products. Possible reaction mechanisms are discussed.

  7-氨基ade啶与2,4-戊二酮的反应生成哒嗪并[6,1-f]嘌呤和5-吡唑基嘧啶。通过X射线分析鉴定了后者的结构。9-氨基-N6-甲基腺嘌呤与2,4-戊二酮的反应生成哒嗪并[1,6-e]嘌呤和席夫碱产物。讨论了可能的反应机理。
• Electrophilic Amination of Adenines. Formation and Characteristics of<i>N</i>-Aminoadenines
  作者：Tetsuya Saga、Toyo Kaiya、Shoji Asano、Kohfuku Kohda

  DOI：10.1080/07328319608002381

  日期：1996.1

  Amination of adenine with H2N-O-SO3H in alkaline media afforded 1-, 3-, 7- and 9-aminoadenine isomers at a ratio of about 1:1:3:1. In neutral media, the product ratio of the isomers changed to about 3:1:1:0. These results were different from the regioselectivity obtained by methylation of adenine with dimethyl sulfate under similar conditions. Amination of adenine with dinitrophenoxyamine in DMF gave 1-aminoadenine as the main product and this regioselectivity was also different from that of methylation with CH.3I. Chemical characteristics of these N-amino adenines are described.
• Substituent Effect of an N-Amino Group on the H-D Exchange of Ring Hydrogens of Adenines Compared with an N-Methyl Group
  作者：Yutaka Kawazoe、Wei Wu、Tetsuya Saga、Isamu Terashima、Ken-ichi Saeki、Kohfuku Kohda

  DOI：10.3987/com-96-7656

  日期：——