1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-bis(4-methylphenyl)- | 333771-77-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-bis(4-methylphenyl)-
• 英文别名: 2-[3-[4,5-bis(4-methylphenyl)-1H-imidazol-2-yl]phenyl]-4,5-bis(4-methylphenyl)-1H-imidazole
• CAS: 333771-77-0
• 化学式: C₄₀H₃₄N₄
• 分子量: 570.737
• InChiKey: AWONTQCQRISENZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  44
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间苯二甲醛 、 4,4'-二甲基联苯甲酰 在 ammonium acetate 、 溶剂黄146 作用下， 反应 3.0h， 以62%的产率得到1H-Imidazole, 2,2'-(1,3-phenylene)bis[4,5-bis(4-methylphenyl)-
  参考文献：
  名称：

  Synthesis and effects on intracellular calcium of some 1,3-bis-(heteroaryl substituted)benzene derivatives

  摘要：

  A series of 1,3-bis-(heteroaryl substituted)benzene derivatives was designed as promising molecules which might increase intracellular Ca2+ level in F2408 fibroblast-like cells by affecting the Ca2+ channels on plasma membrane. Mentioned compounds were obtained by the treatment of isophtalaldehyde with benzil or 1,2-phenylenediamine derivatives. In this way, 13 compounds were synthesised and their structure elucidations were performed by IR, H-1 NMR and mass spectroscopic data and elemental analysis results. Some of the compounds showed Ca2+ being released from the intact cells. (C) 2002 editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0014-827x(02)01246-6