8''-羟基密旋霉素 | 104820-97-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 8''-羟基密旋霉素
• 英文名称: 8''-Hydroxypactamycin
• 英文别名: [(1S,2R,3R,4S,5S)-4-amino-3-(dimethylcarbamoylamino)-1,2-dihydroxy-5-[3-(2-hydroxyacetyl)anilino]-3-(1-hydroxyethyl)-2-methylcyclopentyl]methyl 2-hydroxy-6-methylbenzoate
• CAS: 104820-97-5
• 化学式: C₂₈H₃₈N₄O₉
• 分子量: 574.6
• InChiKey: REZOEBXINKYJRQ-HTTUFWJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  41
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  215
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• PACTAMYCIN ANALOGS AND METHODS OF USE
  申请人：State of Oregon acting by and through the state Board of Higher Education on behalf of

  公开号：US20130231377A1

  公开（公告）日：2013-09-05

  Disclosed are pactamycin analogs, pharmaceutical compositions including the analogs, and methods of using the analogs, such as to inhibit tumor growth or a pathogenic infection such as a bacterial or parasitic infection. The pactamycin analogs have a general formula where R 1 is H, lower aliphatic, amide, acyl, or aminoacyl; R 2 is —C(O)NR 8 R 9 where R 8 and R 9 independently are hydrogen or lower aliphatic, or R 1 and R 2 together form a cyclic structure; R 3 and R 4 independently are hydrogen, hydroxyl, or lower aliphatic, or R 2 and R 3 together form a cyclic structure; R 5 is hydrogen or acyl; R 6 and R 7 independently are hydrogen, hydroxyl, halogen, lower aliphatic, or amino.