Methyl 2,3-di-O-benzyl-6-deoxy-a-D-glucopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 2,3-di-O-benzyl-6-deoxy-a-D-glucopyranoside
• 英文别名: 6-methoxy-2-methyl-4,5-bis(phenylmethoxy)oxan-3-ol
• 化学式: C₂₁H₂₆O₅
• 分子量: 358.4
• InChiKey: LMZPIJSGRUVEAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USES THEREOF
  申请人：Tianjin Institute Of Pharmaceutical Research

  公开号：EP3246324A2

  公开（公告）日：2017-11-22

  The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.

  本发明提供了一种由式I表示的含有脱氧葡萄糖结构的苯基C-葡萄糖苷衍生物、其制备方法、包含其的药物组合物以及其在制备治疗糖尿病药物中的用途，其中取代基R1-R7如说明书中所定义。本发明还提供了一种合成含有脱氧葡萄糖结构的苯基 C-葡萄糖苷衍生物和中间产物的方法。该方法具有操作简单、成本低的优点，适合大规模工业化生产。本发明进一步提供了一种(1S)-1-[4-氯-3-(4-乙氧基苄基)苯基]-1,6-二脱氧-D-葡萄糖和 L-脯氨酸的共晶体及其制备方法和用途。
• EP2933250B1
  申请人：——

  公开号：EP2933250B1

  公开（公告）日：2017-08-09