(5-chloro-3-phenyl-1H-2-indolyl)(4-methylphenyl)methanone | 1426307-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5-chloro-3-phenyl-1H-2-indolyl)(4-methylphenyl)methanone
• 英文别名: (5-chloro-3-phenyl-1H-indol-2-yl)-(4-methylphenyl)methanone
• CAS: 1426307-52-9
• 化学式: C₂₂H₁₆ClNO
• 分子量: 345.828
• InChiKey: LPBDRNCWQQHLPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-bis(4-methylphenacyl)aniline 、 2-氨基-5-氯二苯甲酮 在 camphor-10-sulfonic acid 作用下， 以 乙醇 为溶剂， 反应 1.8h， 以82%的产率得到(5-chloro-3-phenyl-1H-2-indolyl)(4-methylphenyl)methanone
  参考文献：
  名称：

  Reaction of Diphenacylanilines with 2-Aminobenzophenone: An Abnormal Friedlander Reaction Yielding Indoles

  摘要：

  This article describes an abnormal Friedlander reaction between diphenacylaniline and 2-aminobenzophenone in the presence of a catalytic amount of (+/-)-camphorsulfonic acid yielding 2-aroyl-3-arylindoles in quantitative yield.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.627524

文献信息

• Reaction of Diphenacylanilines with 2-Aminobenzophenone: An Abnormal Friedlander Reaction Yielding Indoles
  作者：Nidhin Paul、Shanmugam Muthusubramanian

  DOI：10.1080/00397911.2011.627524

  日期：2013.4.18

  This article describes an abnormal Friedlander reaction between diphenacylaniline and 2-aminobenzophenone in the presence of a catalytic amount of (+/-)-camphorsulfonic acid yielding 2-aroyl-3-arylindoles in quantitative yield.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.