8-乙氧基-2-苯基环庚并[d]咪唑 | 153447-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 8-乙氧基-2-苯基环庚并[d]咪唑
• 英文名称: 2-Phenyl-8-ethoxycycloheptimidazole
• 英文别名: 4-ethoxy-2-phenylcyclohepta[d]imidazole
• CAS: 153447-99-5
• 化学式: C₁₆H₁₄N₂O
• 分子量: 250.29
• InChiKey: OULXFNCZTZKFKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• BRADYKININ RECEPTOR AGONISTS AND USES THEREOF TO TREAT OCULAR HYPERTENSION AND GLAUCOMA
  申请人：Combrink Keith D.

  公开号：US20120046285A1

  公开（公告）日：2012-02-23

  The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.

  这项发明提供了用于治疗和/或预防与眼内压增高相关的眼部疾病的组合物和方法。具体来说，这些化合物是激肽酶激动剂。
• Treatment of pulmonary vasoconstriction and asthma
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP1466641A1

  公开（公告）日：2004-10-13

  This invention inter alia relates to a device for the administration of an active agent in a propellant gas into the respiratory system of a patient, said device containing said active agent (106) and a propellant gas in compressed or liquified form, characterised in that said active agent is a phophodiesterase inhibitor.

  本发明尤其涉及一种将活性剂与推进气体一起注入患者呼吸系统的装置，所述装置包含所述活性剂（106）和压缩或液化形式的推进气体，其特征在于所述活性剂是一种噬磷酸二酯酶抑制剂。
• Methods, compositions, and kits for the treatment of ophthalmic disorders
  申请人：CombinatoRx, Inc.

  公开号：EP2218442A1

  公开（公告）日：2010-08-18

  The invention features methods, compositions and kits comprising a corticosteroid and a non-steroidal immunophilin-dependent immunosuppressant for treating an ophthalmic disorder in a patient, wherein at least one of said corticosteroid and said non-steroidal immunophilin-dependent immunosuppressant is present at a low concentration, in particular wherein said corticosteroid is prednisolone acetate and said non-steroidal immunophilin-dependent immunosuppressant is cyclosporine A.

  本发明的特征是包含皮质类固醇和非类固醇免疫嗜血素依赖性免疫抑制剂的方法、组合物和试剂盒，用于治疗患者的眼科疾病、其中，所述皮质类固醇和所述非类固醇免疫嗜血素依赖性免疫抑制剂中至少有一种以低浓度存在，特别是所述皮质类固醇为醋酸泼尼松龙，所述非类固醇免疫嗜血素依赖性免疫抑制剂为环孢素 A。
• Nitric oxide delivery device
  申请人：The General Hospital Corporation

  公开号：EP2514473A1

  公开（公告）日：2012-10-24

  A gas delivery device is disclosed, the gas delivery device comprising a lumen configured to route a gas into the respiratory system of a mammal, a first meter configured to measure the concentration of nitric oxide gas present in the lumen, a second meter configured to measure the rate of gas flow in the lumen, and a dosimeter that integrates the concentration of nitric oxide measured in the lumen with the rate of gas flow measured in the lumen to determine the amount of nitric oxide delivered by the device to the respiratory system of the mammal. The device may further comprise a vessel with pressurized gas comprising with at least 1 ppm nitric oxide, the vessel having a mechanism for controllably releasing the pressurized gas into the lumen or into a chamber in communication with the lumen. The release of the pressurized gas may be triggered by negative inspiratory pressure of the mammal and limited to the inspiratory cycle of respiration.

  本发明公开了一种气体输送装置，该气体输送装置包括一个用于将气体输送到哺乳动物呼吸系统的管腔、一个用于测量管腔中一氧化氮气体浓度的第一测量仪、一个用于测量管腔中气体流速的第二测量仪，以及一个剂量计，该剂量计将管腔中测量到的一氧化氮浓度与管腔中测量到的气体流速进行整合，以确定该装置输送到哺乳动物呼吸系统中的一氧化氮量。该装置可进一步包括一个装有加压气体的容器，加压气体中至少含有 1 ppm 的一氧化氮，该容器具有一个机构，用于将加压气体可控地释放到管腔中或释放到与管腔相通的腔室中。加压气体的释放可由哺乳动物的负吸气压力触发，并仅限于呼吸的吸气周期。
• Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US10842812B2

  公开（公告）日：2020-11-24

  Methods of promoting hypoxia or the hypoxia response for the treatment or prevention of mitochondrial dysfunction and oxidative stress disorders are described. Methods for screening for targets of mitochondrial dysfunction and oxidative stress disorders are also described.

  描述了促进缺氧或缺氧反应以治疗或预防线粒体功能障碍和氧化应激紊乱的方法。还描述了筛选线粒体功能障碍和氧化应激紊乱靶标的方法。