8-巯基腺苷 | 15830-55-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 8-巯基腺苷
• 中文别名: 7,8-二氢-8-硫氧代腺苷酸；7,8-二氢-8- 硫氧代腺苷酸
• 英文名称: 2-(6-Amino-8-sulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 英文别名: 6-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7H-purine-8-thione
• CAS: 15830-55-4；3001-45-4；15830-61-2
• 化学式: C₁₀H₁₃N₅O₄S
• 分子量: 299.31
• InChiKey: QILZVYQRHGBEAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  141
• 氢给体数：
  5
• 氢受体数：
  9

安全信息

• 储存条件：
  存储条件：2-8°C，避光、干燥密封保存。

文献信息

• Method for Increasing Plant Stress Tolerance and Seed Dormancy
  申请人：The Australian National University

  公开号：US20180355369A1

  公开（公告）日：2018-12-13

  The present invention provides a method for increasing the levels of 3′-phosphoadenosine-5′-phosphate (PAP) or a derivative or analogue thereof in cells of said plant compared to an untreated or wild-type plant grown under the same stress conditions. The methods may comprise administration to the plant and/or the soil it is growing in of: PAP or a derivative or analogue thereof, a substance that enhances or promotes synthesis or accumulation of PAP or said derivative or analogue thereof; or a substance that inhibits or compromises an activity metabolising or removing PAP or said derivative or analogue thereof. Alternatively, the methods may comprise genetic modification of cells of said plant which modifications allow for increased accumulation of PAP or a derivative or analogue thereof in cells of said plant (or in seeds thereof) at least under stress conditions compared to a wild-type plant. The methods find particular application in increasing the tolerance of plants to abiotic stress conditions, which may be selected from increased salinity, increased sodium levels, drought, light stress and pH stress. The present invention also provides a method for extending the dormancy of a seed, as compared to an untreated seed, said method comprising accumulating in cells within said seed an increased level of PAP or a derivative or analogue thereof compared to an untreated or wild-type seed.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING FAT METABOLISM<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES PERMETTANT DE MODULER LE METABOLISME DES GRAISSES
  申请人：OBETHERAPY BIOTECHNOLOGY

  公开号：WO2004037159A2

  公开（公告）日：2004-05-06

  Methods, compositions and methods of identifying candidate compounds, for modulating fat metabolism and/or inhibiting Apobec-1 activity are provided.