N-tert-butyl-5-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-amine | 601502-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-tert-butyl-5-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-amine
• CAS: 601502-01-6
• 化学式: C₁₉H₂₃N₃
• mdl: MFCD03744099
• 分子量: 293.412
• InChiKey: XXNHPJNPQRMQHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-6-甲基吡啶 、 异氰酸叔丁酯 、 对甲基苯甲醛 在 氯化铋 作用下， 以 neat (no solvent) 为溶剂， 以94%的产率得到N-tert-butyl-5-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-amine
  参考文献：
  名称：

  Three Novel Sequential Reactions for the Facile Synthesis of a Library of Bisheterocycles Possessing the 3-Aminoimidazo[1,2-a]pyridine Core Cata­lyzed by Bismuth(III) Chloride

  摘要：

  Novel, one-pot, two-step, sequential protocols for the synthesis of 1,4-phenylene bisheterocyclic compounds have been developed. Successive sequencing of the Groebke-Blackburn-Bienayme reaction with Ugi-azide, Hantzsch and Biginelli reactions results in rapid and efficient formation of bisheterocyclic compounds. A simple, fast and high yielding method for the synthesis of 3-aminoimidazo[1,2-a]pyridines catalyzed by bismuth(III) chloride under solvent-free conditions is reported. Bismuth(III) chloride is also an efficient catalyst for the Ugi-azide reaction under solvent free conditions.

  DOI：

  10.1055/s-0032-1318221