(4R)-3-methylidene-4-phenyloxolan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (4R)-3-methylidene-4-phenyloxolan-2-one
• 化学式: C₁₁H₁₀O₂
• 分子量: 174.2
• InChiKey: SRBVGIMLMRHNHD-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SAFER, POTENT, AND FAST ACTING ANTIMICROBIAL AGENTS
  申请人：Purdue Research Foundation

  公开号：US20210317099A1

  公开（公告）日：2021-10-14

  The present invention generally relates to compounds, composition matters, and methods for the treatment of a patient with an infection caused by microorganisms, including bacterial, viral, and fungal infections. In particular, this disclosure relates to safe, highly potent and fast acting antimicrobial agents α-methylene and α-aminomethyl lactones, lactams, iminolactones, and iminolactams, thiolactones, thionolactones, thiolactams, and thionolactams having a formula of I, II, III, or IV, for the treatment of viral and bacterial infections, especially for infections caused by methicillin-resistant Staphylococcus aureus (MRSA).