1-[2-Hydroxy-2-(1-hydroxycyclopropyl)ethyl]cyclopropan-1-ol | 868630-82-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-Hydroxy-2-(1-hydroxycyclopropyl)ethyl]cyclopropan-1-ol
• CAS: 868630-82-4
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: OBJWXPNUAJNYHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-[2-Hydroxy-2-(1-hydroxycyclopropyl)ethyl]cyclopropan-1-ol 在 copper(II) sulfate 、 三乙胺 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 Methanesulfonic acid 1-(5,5-dimethyl-4,6-dioxa-spiro[2.5]oct-7-yl)-cyclopropyl ester
  参考文献：
  名称：

  Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage

  摘要：

  Ethoxycarbonyl groups in O-THP protected racemic diethyl malate I were differentiated by their reductive cyclopropanation with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide and subsequent site-selective C1-C2, C2-C3 or both C1-C2 and C1-C3 ring cleavage of the cyclopropyl groups of the resulting bis-cyclopropanol 2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.076
• 作为产物：
  描述：

  1-[2-(1-hydroxycyclopropyl)-2-(oxan-2-yloxy)ethyl]cyclopropan-1-ol 在 4-甲基苯磺酸吡啶 作用下， 以 甲醇 为溶剂， 以79%的产率得到1-[2-Hydroxy-2-(1-hydroxycyclopropyl)ethyl]cyclopropan-1-ol
  参考文献：
  名称：

  Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage

  摘要：

  Ethoxycarbonyl groups in O-THP protected racemic diethyl malate I were differentiated by their reductive cyclopropanation with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide and subsequent site-selective C1-C2, C2-C3 or both C1-C2 and C1-C3 ring cleavage of the cyclopropyl groups of the resulting bis-cyclopropanol 2. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.076

文献信息

• Preparation of isopropylidene acetals from butane-1,2,4-triol and its cyclopropane congeners
  作者：Konstantin N. Prokhorevich、Andrei V. Bekish

  DOI：10.1016/j.tetlet.2010.05.126

  日期：2010.8

  Features of isopropylidene acetal synthesis from butane-1,2,4-triol and its cyclopropane congeners were studied. Procedures for the preparation and purification of the respective acetonides have been developed.

  研究了由1,2,4-丁三醇及其环丙烷同源物合成异亚丙基缩醛的特性。已经开发了制备和纯化各个丙酮化物的方法。
• Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage
  作者：Andrei V. Bekish、Oleg G. Kulinkovich

  DOI：10.1016/j.tetlet.2005.08.076

  日期：2005.10

  Ethoxycarbonyl groups in O-THP protected racemic diethyl malate I were differentiated by their reductive cyclopropanation with ethylmagnesium bromide in the presence of titanium(IV) isopropoxide and subsequent site-selective C1-C2, C2-C3 or both C1-C2 and C1-C3 ring cleavage of the cyclopropyl groups of the resulting bis-cyclopropanol 2. (c) 2005 Elsevier Ltd. All rights reserved.