2-(4-(4-Fluorobenzoyl)piperidin-1-yl)-2'-acetonaphthone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-(4-Fluorobenzoyl)piperidin-1-yl)-2'-acetonaphthone
• 英文别名: 2-[4-(4-fluorobenzoyl)piperidin-1-yl]-1-naphthalen-2-ylethanone
• 化学式: C₂₄H₂₂FNO₂
• 分子量: 375.4
• InChiKey: WPFPDSUMDURRRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Combination of a NMDA-receptor ligand and a compound with 5-HT6 receptor affinity
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1902733A1

  公开（公告）日：2008-03-26

  The present invention relates to an active substance combination comprising at least one compound with 5-HT6 receptor affinity, and at least NMDA-receptor ligand, a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament.

  本发明涉及一种由至少一种具有 5-HT6 受体亲和力的化合物和至少一种 NMDA 受体配体组成的活性物质组合、一种包含所述活性物质组合的药物，以及使用所述活性物质组合制造药物。
• Topical compositions and methods for treating pain
  申请人：——

  公开号：US20030082214A1

  公开（公告）日：2003-05-01

  Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.

  治疗疼痛的局部组合物和方法。本发明提供水包油乳剂，包含抗抑郁剂、NMDA 受体拮抗剂、亲脂性成分、水和表面活性剂。当局部给药到完整的皮肤上时，这些组合物会产生局部麻醉效果，从而治疗或预防疼痛，例如神经性疼痛。
• Sterile, breathable patch for treating wound pain
  申请人：——

  公开号：US20030082225A1

  公开（公告）日：2003-05-01

  An intradermal patch having a permeable backing coated with a polyvinylpyrrolidone-based hydrogel and containing one or more local anesthetics. The patch is breathable, non-irritating upon application and removal, soothing, and sterile. The patch is useful for treating the pain associated with non-intact skin indications.

  一种皮内贴片，其透气衬底涂有聚乙烯吡咯烷酮水凝胶，并含有一种或多种局部麻醉剂。该贴片透气性好，贴上和取下时无刺激、舒缓且无菌。该贴片可用于治疗与非接触性皮肤指征相关的疼痛。
• SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS
  申请人：CAMBRIDGE NEUROSCIENCE RESEARCH, INC.

  公开号：EP0584088A1

  公开（公告）日：1994-03-02
• EP0584088A4
  申请人：——

  公开号：EP0584088A4

  公开（公告）日：1995-01-18