(1S,3S,4S)-3,4-dihydroxycyclohexane-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,3S,4S)-3,4-dihydroxycyclohexane-1-carboxylic acid
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: PTPROPUVXIZJPL-ZLUOBGJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• PYRROLIDINE ETHER DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS
  申请人：Jablonski Philippe

  公开号：US20090306043A1

  公开（公告）日：2009-12-10

  The present invention relates to compounds of formula I wherein R 1 , R 2 , R 3 , R′, Ar, m, n, and o are as defined herein. The invention also relates to pharmaceutical compositions containing compounds of formula I and methods for the manufacture of such compounds and compositions. Compounds of the invention are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).

  本发明涉及式I的化合物，其中R1、R2、R3、R′、Ar、m、n和o如本文所定义。该发明还涉及含有式I化合物的药物组合物，以及制备这种化合物和组合物的方法。本发明的化合物是用于治疗抑郁症、疼痛、精神病、帕金森病、精神分裂症、焦虑和注意力缺陷多动障碍（ADHD）的高潜力NK-3受体拮抗剂。
• Production Of Polyketides And Other Natural Products
  申请人：Gregory Matthew Alan

  公开号：US20090253732A1

  公开（公告）日：2009-10-08

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

  本发明涉及聚酮类化合物和其他天然产物的生产，以及化合物库和独特新化合物的制备。因此，本发明提供了17-去甲基拉帕霉素及其类似物，包括重组菌株的制备方法，以及本发明化合物的分离和用途。此外，本发明还提供了将17-去甲基拉帕霉素及其类似物用于诱导或维持免疫抑制、促进神经再生或治疗癌症、B细胞恶性肿瘤、真菌感染、移植排斥、移植物抗宿主病、自身免疫性疾病、炎症性血管疾病和纤维化疾病的调节。
• RAPAMYCIN ANALOGUES AND THEIR PHARMACEUTICAL USE
  申请人：Isomerase Therapeutics Limited

  公开号：US20160176893A1

  公开（公告）日：2016-06-23

  Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

  小说雷帕霉素类似物及其生产方法，具有FKBP和/或MIP抑制活性，同时减少mTOR抑制活性，具有治疗潜力，例如作为细菌毒力抑制剂。
• 17-Desmethylrapamycin and analogues thereof, methods for their production and their use as immunosupressants, anticancer agents, antifungal agents etc.
  申请人：Biotica Technology Limited

  公开号：EP2471797A2

  公开（公告）日：2012-07-04

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

  本发明涉及多酮类化合物和其他天然产物的生产，以及化合物库和单个新型化合物。因此，在一个方面，本发明提供了 17-去甲基拉帕霉素及其类似物、其生产方法（包括重组菌株）以及本发明化合物的分离和用途。在另一个方面，本发明提供了17-去甲基拉帕霉素及其类似物在诱导或维持免疫抑制、刺激神经元再生或治疗癌症、B细胞恶性肿瘤、真菌感染、移植排斥反应、移植物对宿主疾病、自身免疫性疾病、炎症性血管疾病和纤维化疾病以及调节伤口愈合中的用途。
• PRODUCTION OF POLYKETIDES
  申请人：Buck Institute for Research on Aging

  公开号：EP1521828B1

  公开（公告）日：2015-07-01