ditert-butyl-(4-methoxyphenoxy)silane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ditert-butyl-(4-methoxyphenoxy)silane
• 化学式: C₁₅H₂₆O₂Si
• 分子量: 266.456
• InChiKey: RSECQFSZNLIKQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  ditert-butyl-(4-methoxyphenoxy)silane 在 N-溴代丁二酰亚胺(NBS) 、 水 、 sodium hydroxide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 Ditert-butyl-hydroxy-(4-methoxyphenoxy)silane
  参考文献：
  名称：

  Silanol: A Traceless Directing Group for Pd-Catalyzed o-Alkenylation of Phenols

  摘要：

  A silanol-directed, Pd(II)-catalyzed C-H alkenylation of phenols is reported. This work features silanol, as a novel traceless directing group, and a directed o-C-H alkenylation of phenols. This new method allows for efficient synthesis of diverse alkenylated phenols, including an estrone derivative.

  DOI：

  10.1021/ja204924j
• 作为产物：
  描述：

  di-tert-butylchlorosilane 、 4-甲氧基苯酚 在 咪唑 作用下， 以 四氢呋喃 为溶剂， 生成 ditert-butyl-(4-methoxyphenoxy)silane
  参考文献：
  名称：

  Silanol: A Traceless Directing Group for Pd-Catalyzed o-Alkenylation of Phenols

  摘要：

  A silanol-directed, Pd(II)-catalyzed C-H alkenylation of phenols is reported. This work features silanol, as a novel traceless directing group, and a directed o-C-H alkenylation of phenols. This new method allows for efficient synthesis of diverse alkenylated phenols, including an estrone derivative.

  DOI：

  10.1021/ja204924j

文献信息

• Silanol: A Traceless Directing Group for Pd-Catalyzed <i>o</i>-Alkenylation of Phenols
  作者：Chunhui Huang、Buddhadeb Chattopadhyay、Vladimir Gevorgyan

  DOI：10.1021/ja204924j

  日期：2011.8.17

  A silanol-directed, Pd(II)-catalyzed C-H alkenylation of phenols is reported. This work features silanol, as a novel traceless directing group, and a directed o-C-H alkenylation of phenols. This new method allows for efficient synthesis of diverse alkenylated phenols, including an estrone derivative.