(5-Acetamido-3,4-diacetyloxy-6-carbamimidoylsulfanyloxan-2-yl)methyl acetate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-Acetamido-3,4-diacetyloxy-6-carbamimidoylsulfanyloxan-2-yl)methyl acetate
• 化学式: C₁₅H₂₃N₃O₈S
• 分子量: 405.4
• InChiKey: HKFFTLKKGVRASK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  192
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS<br/>[FR] COMPOSITIONS ET MÉTHODES ASSURANT UNE MEILLEURE ABSORPTION INTESTINALE DE COMPOSÉS OLIGOMÈRES CONJUGUÉS
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2015188194A1

  公开（公告）日：2015-12-10

  Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods are provided for oral delivery of conjugated oligomeric compounds. In certain embodiments, the oligomeric compounds are conjugated to one or more N-acetylgalactosamines or N-acetylgalactosamine analogues.

  本文提供了用于非肠内递送共轭寡聚化合物的组合物和方法。在某些实施方式中，提供了用于口服递送共轭寡聚化合物的组合物和方法。在某些实施方式中，这些寡聚化合物与一个或多个N-乙酰半乳糖胺或N-乙酰半乳糖胺类似物共轭。
• [EN] CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS ANTISENS CONJUGUÉS ET LEUR UTILISATION
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2015179693A1

  公开（公告）日：2015-11-26

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the gomeric compounds are conjugated to N-Acetylgalactosamine or to N-Acetylgalactosamine analogues.

  本文提供了具有共轭基团的寡聚化合物。在某些实施例中，这些寡聚化合物与N-乙酰半乳糖或N-乙酰半乳糖类似物结合。
• Imaging Agent
  申请人：Davis Benjamin Guy

  公开号：US20080311048A1

  公开（公告）日：2008-12-18

  The invention provides a conjugate comprising an iron containing colloidal particle, the particle being conjugated to one or more sugar targeting moieties. The conjugate is useful as a contrast agent in medical imaging, particularly in magnetic resonance imaging (MRI). The agents of the present invention may cross the blood brain barrier and so may be particularly useful in the monitoring or diagnosis of conditions affecting the brain.

  本发明提供了一种共轭物，包括含铁胶体颗粒，该颗粒与一个或多个糖靶向基团结合。该共轭物可用作医学成像中的对比剂，特别是在磁共振成像（MRI）中。本发明的试剂可以穿过血脑屏障，因此在监测或诊断影响大脑的疾病方面可能特别有用。
• Conjugated antisense compounds and their use
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US10570169B2

  公开（公告）日：2020-02-25

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the gomeric compounds are conjugated to N-Acetylgalactosamine or to N-Acetylgalactosamine analogues.

  本文提供的是具有共轭基团的低聚化合物。在某些实施方案中，低聚物与 N-乙酰半乳糖胺或 N-乙酰半乳糖胺类似物共轭。
• COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US20170145424A1

  公开（公告）日：2017-05-25

  Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods are provided for oral delivery of conjugated oligomeric compounds. In certain embodiments, the oligomeric compounds are conjugated to one or more N-acetylgalactosamines or N-acetylgalactosamine analogues.