4-methyl-6-(2-oxo-2-phenyl-ethyl)-5-phenyl-1H-pyrimidin-2-one | 50324-14-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyl-6-(2-oxo-2-phenyl-ethyl)-5-phenyl-1H-pyrimidin-2-one
• 英文别名: 2-Hydroxy-4-methyl-5-phenyl-6-benzoylmethylpyrimidine；6-methyl-4-phenacyl-5-phenyl-1H-pyrimidin-2-one
• CAS: 50324-14-6
• 化学式: C₁₉H₁₆N₂O₂
• 分子量: 304.348
• InChiKey: FGZJCDOHGOOXFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrimidones with antiviral properties
  申请人：Axxima Pharmaceuticals Aktiengesellschaft

  公开号：EP1389461A1

  公开（公告）日：2004-02-18

  The present invention relates to vinylpyrimidine-2-one derivatives of the general formula (I): Furthermore the present invention relates to vinylpyrimidine-2-one derivatives and of the general formula (Ia): wherein R1 to R6 in formula (I) and in formula (Ia) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties. The compounds are used as antivirals, especially against herpes and HCMV (Human Cytomegalovirus).

  本发明涉及一般式(I)的乙烯基嘧啶-2-酮衍生物，以及一般式(Ia)的乙烯基嘧啶-2-酮衍生物，其中在式(I)和式(Ia)中，R1至R6独立地表示各种不同的取代基，包括烷基，芳基，芳基烷基，烷基芳基，杂环芳基和单官能团。该化合物可用作抗病毒药物，特别是用于抗疱疹病毒和人类巨细胞病毒(HCMV)。
• [EN] PYRIMIDONES AS ANTIVIRAL AGENTS<br/>[FR] PYRIMIDONES EN TANT QU'AGENTS ANTIVIRAUX
  申请人：AXXIMA PHARMACEUTICALS AG

  公开号：WO2004016271A1

  公开（公告）日：2004-02-26

  The present invention relates to vinylpyrimidine-2-one derivatives of general formula (I). Furthermore the present invention relates to vinylpyrimidine-2-one derivatives and of general formula (Ia), wherein R1 to R6 in formula (I) and in formula (Ia) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties.