7-methyl-1,4-dipyridin-2-yl-6H-pyrrolo[3,4-g]phthalazine-6,8(7H)-dione | 1147699-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-methyl-1,4-dipyridin-2-yl-6H-pyrrolo[3,4-g]phthalazine-6,8(7H)-dione
• 英文别名: 7-Methyl-1,4-dipyridin-2-ylpyrrolo[3,4-g]phthalazine-6,8-dione；7-methyl-1,4-dipyridin-2-ylpyrrolo[3,4-g]phthalazine-6,8-dione
• CAS: 1147699-28-2
• 化学式: C₂₁H₁₃N₅O₂
• 分子量: 367.367
• InChiKey: YOWRFPADTXDDKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  88.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-methyl-1,4-dipyridin-2-yl-6H-pyrrolo[3,4-g]phthalazine-6,8(7H)-dione 、 2,5-Norbornadiene 以 氯仿 为溶剂， 以37%的产率得到2-methyl-5,8-dipyridin-2-yl-1H-benz[f]isoindole-1,3(2H)-dione
  参考文献：
  名称：

  刚性双环[2.2.1]庚-2-烯（= 8,9,10-三降冰片烯）和1,4-二吡啶-2-基邻苯二甲腈作为立体选择性偶联剂的脂环族分子。

  摘要：

  Abstractmagnified imageFor the preparation of rigid polycyclic molecules from 8,9,10‐trinorbornenes (=bicyclo[2.2.1]hept‐2‐enes), 1,4‐dipyridin‐2‐ylphthalazines were used. Cycloaddition reactions with trinorbornenes gave coupled products in a stereoselective manner. In these reactions, the phthalazines delivered a new bicyclo[2.2.2] moiety at the junction of two trinorbornene units, which could bear appropriate functional groups (Schemes 4and5). The crystal structure of a key cycloadduct,i.e., of18was also determined (Fig. 2). Relative reactivities for a series of phthalazines (Fig. 3) were estimated by density‐functional‐theory (DFT) calculations at the B3LYP/6‐31G* level (Table). The calculations indicated an increase of reactivity when the aromaticity of the phthalazine moiety is decreased. Finally, experimentally observed stereoselectivities of the phthalazine reactions with trinorbornenes were readily predicted by DFT calculations (Fig. 4).

  DOI：

  10.1002/hlca.200800205
• 作为产物：
  描述：

  在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以103 mg的产率得到7-methyl-1,4-dipyridin-2-yl-6H-pyrrolo[3,4-g]phthalazine-6,8(7H)-dione
  参考文献：
  名称：

  刚性双环[2.2.1]庚-2-烯（= 8,9,10-三降冰片烯）和1,4-二吡啶-2-基邻苯二甲腈作为立体选择性偶联剂的脂环族分子。

  摘要：

  Abstractmagnified imageFor the preparation of rigid polycyclic molecules from 8,9,10‐trinorbornenes (=bicyclo[2.2.1]hept‐2‐enes), 1,4‐dipyridin‐2‐ylphthalazines were used. Cycloaddition reactions with trinorbornenes gave coupled products in a stereoselective manner. In these reactions, the phthalazines delivered a new bicyclo[2.2.2] moiety at the junction of two trinorbornene units, which could bear appropriate functional groups (Schemes 4and5). The crystal structure of a key cycloadduct,i.e., of18was also determined (Fig. 2). Relative reactivities for a series of phthalazines (Fig. 3) were estimated by density‐functional‐theory (DFT) calculations at the B3LYP/6‐31G* level (Table). The calculations indicated an increase of reactivity when the aromaticity of the phthalazine moiety is decreased. Finally, experimentally observed stereoselectivities of the phthalazine reactions with trinorbornenes were readily predicted by DFT calculations (Fig. 4).

  DOI：

  10.1002/hlca.200800205

文献信息

• Rigid Alicyclic Molecules from Bicyclo[2.2.1]hept-2-enes (=8,9,10-Trinorbornenes) and 1,4-Dipyridin-2-ylphthalazines as Stereoselective Coupling Agents
  作者：Davor Margetić、Yasujiro Murata、Koichi Komatsu、Željko Marinić

  DOI：10.1002/hlca.200800205

  日期：2009.2

  Abstractmagnified imageFor the preparation of rigid polycyclic molecules from 8,9,10‐trinorbornenes (=bicyclo[2.2.1]hept‐2‐enes), 1,4‐dipyridin‐2‐ylphthalazines were used. Cycloaddition reactions with trinorbornenes gave coupled products in a stereoselective manner. In these reactions, the phthalazines delivered a new bicyclo[2.2.2] moiety at the junction of two trinorbornene units, which could bear appropriate functional groups (Schemes 4and5). The crystal structure of a key cycloadduct,i.e., of18was also determined (Fig. 2). Relative reactivities for a series of phthalazines (Fig. 3) were estimated by density‐functional‐theory (DFT) calculations at the B3LYP/6‐31G* level (Table). The calculations indicated an increase of reactivity when the aromaticity of the phthalazine moiety is decreased. Finally, experimentally observed stereoselectivities of the phthalazine reactions with trinorbornenes were readily predicted by DFT calculations (Fig. 4).