5-(4-methylphenoxy)-2-(2-methylphenyl)-1H-isoindole-1,3(2H)-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(4-methylphenoxy)-2-(2-methylphenyl)-1H-isoindole-1,3(2H)-dione
• 英文别名: 5-(4-methylphenoxy)-2-(2-methylphenyl)isoindole-1,3-dione
• 化学式: C₂₂H₁₇NO₃
• 分子量: 343.4
• InChiKey: SHOXXVPPBAOKGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION
  申请人：Dendreon Corporation

  公开号：US20130190296A1

  公开（公告）日：2013-07-25

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Tip-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Tip-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物，以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和用于降低Trp-p8表达细胞的存活率和/或抑制其生长的方法，用于激活Trp-p8介导的阳离子流入的方法，用于刺激细胞凋亡和/或坏死的方法，以及相关用于治疗疾病的方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症以及与Trp-p8表达相关的良性前列腺增生等其他疾病。