8-羟基喹啉-5,7-二磺酸 | 31568-84-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 8-羟基喹啉-5,7-二磺酸
• 英文名称: 8-Hydroxychinolin-5,7-disulfonsaeure
• 英文别名: 8-Hydroxyquinoline-5,7-disulphonic acid；8-hydroxyquinoline-5,7-disulfonic acid
• CAS: 31568-84-0
• 化学式: C₉H₇NO₇S₂
• 分子量: 305.289
• InChiKey: XSULSEYNDUGHLM-UHFFFAOYSA-N

物化性质

• 密度：
  1.899±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  159
• 氢给体数：
  3
• 氢受体数：
  8

安全信息

• 海关编码：
  2933499090

文献信息

• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.