α-Methyl p-chlorophenylalanine | 15080-35-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: α-Methyl p-chlorophenylalanine
• 英文别名: 2-<4-Chlor-benzyl>-2-amino-propionsaeure；2-Amino-3-(4-chlorophenyl)-2-methylpropanoic acid
• CAS: 15080-35-0
• 化学式: C₁₀H₁₂ClNO₂
• 分子量: 213.664
• InChiKey: IVPYXMQYUYFSFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-(4-Chlor-benzyl)-5-methyl-2.4-dioxo-imidazolidin 在 barium dihydroxide 作用下， 生成 α-Methyl p-chlorophenylalanine
  参考文献：
  名称：

  酪氨酸羟化酶抑制剂。取代的芳香族氨基酸的合成和活性。

  摘要：

  DOI：

  10.1021/jm00318a005

文献信息

• α-methyl amino acids by catalytic phase-transfer alkylations
  作者：Martin J. O'Donnell、Brigitte LeClef、David B. Rusterholz、Léon Ghosez、Jean-Pierre Antoine、Mirtha Navarro

  DOI：10.1016/s0040-4039(00)88719-5

  日期：1982.1

  The α-methyl amino acids, α-methyl p-chlorophenylalanine, α-methyl p-tyrosine, α-methyl m-tyrosine and α-methyl DOPA have been prepared in good yields from amino ester hydrochlorides. The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of mono alkyl amino acids.

  由氨基酯盐酸盐以高收率制备了α-甲基氨基酸，α-甲基对氯苯基丙氨酸，α-甲基对酪氨酸，α-甲基间酪氨酸和α-甲基DOPA。该方法的关键步骤是单烷基氨基酸的席夫碱衍生物的催化相转移烷基化。
• Monomethylvaline Compounds Having Phenylalanine Side-Chain Replacements at the C-Terminus
  申请人：Doronina Svetlana O.

  公开号：US20090018086A1

  公开（公告）日：2009-01-15

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供了MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类类似物，其中包括C-末端苯丙氨酸残基侧链替换或修饰，这些类似物可以单独提供或通过各种连接剂连接到配体上。相关的结合物可以针对特定细胞类型，提供治疗效果。
• MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS
  申请人：Seattle Genetics, Inc.

  公开号：US20130123465A1

  公开（公告）日：2013-05-16

  Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

  提供了MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽类类似物，其具有C-末端苯丙氨酸残基侧链替换或修饰，可单独提供或通过各种连接剂连接到配体上。相关的结合物可以定向特定的细胞类型，以提供治疗效益。
• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING -AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP1870403A1

  公开（公告）日：2007-12-26

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• Optically active quaternary ammonium salt having axial asymmetry and process for producing alpha-amino acid and derivative thereof with the same
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP2484667A1

  公开（公告）日：2012-08-08

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。