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8-羟基辛酸乙酯 | 93892-06-9

中文名称
8-羟基辛酸乙酯
中文别名
——
英文名称
ethyl 8-hydroxyoctanoate
英文别名
——
8-羟基辛酸乙酯化学式
CAS
93892-06-9
化学式
C10H20O3
mdl
MFCD03412488
分子量
188.267
InChiKey
DWFKLFYVEOSPAG-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • LogP:
    1.936 (est)

计算性质

  • 辛醇/水分配系数(LogP):
    1.9
  • 重原子数:
    13
  • 可旋转键数:
    9
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.9
  • 拓扑面积:
    46.5
  • 氢给体数:
    1
  • 氢受体数:
    3

安全信息

  • 海关编码:
    2918199090

SDS

SDS:47bfeb18691b45c5bd22646e90beaae2
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上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

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文献信息

  • [EN] SITE-SPECIFIC RADIOFLUORINATION OF PEPTIDES WITH 8-[18F]-FLUOROOCTANOIC ACID CATALYZED BY LIPOIC ACID LIGASE<br/>[FR] RADIOFLUORATION SPÉCIFIQUE DE SITE DE PEPTIDES AVEC DE L'ACIDE 8-[18F]FLUOROOCTANOÏQUE CATALYSÉE PAR UNE ACIDE LIPOÏQUE LIGASE
    申请人:UNIV CALIFORNIA
    公开号:WO2017095806A1
    公开(公告)日:2017-06-08
    New methodologies for site-specifically radiolabeling proteins with the PET isotope [18F] are required to generate high quality radiotracers for imaging in both the preclinical and clinical settings. The enzymatic radiofluorination overcomes many of the limitations encountered to date with purely chemical approaches. The bacterial enzyme lipoic acid ligase was used to conjugate [18F]-fluorooctanoic acid to both a small peptide and a Fab antibody fragment. Labeling was site-specific and highly efficient under mild aqueous conditions using small amounts of peptide/protein (1-10 nmol). The labeled construct retained full epitope binding affinity and was stable in mouse serum. Using an optimized reaction scheme, mCi quantities of [18F]-Fab were generated, an amount sufficient for human imaging.
    用PET同位素[18F]对蛋白质进行特异性标记的新方法对于在临床前和临床环境中生成高质量放射示踪剂是必需的。酶促放反应克服了迄今为止纯化学方法所遇到的许多限制。细菌酶辛酸连接酶被用于将[18F]-辛酸与小肽和Fab抗体片段结合。在温和性条件下,使用少量的肽/蛋白质(1-10 nmol),标记是特异性的且高效的。标记的构建物保留了完整的抗原结合亲和力,并在小鼠血清中稳定。使用优化的反应方案,产生了足够进行人体成像的mCi数量的[18F]-Fab。
  • Tin-free reductive photochemical carboxymethylation of olefins with α-alkylthioacetates
    作者:Lisa X. Deng、Andrei G. Kutateladze
    DOI:10.1016/s0040-4039(97)10095-8
    日期:1997.11
    An efficient tin-free reductive photochemical carboxymethylation of olefins with α-alkylthioacetates is developed, which (a) is an experimentally simple technique furnishing substituted derivatives of fatty acids in moderate to good yields, (b) is compatible with polar/protic functional groups and solvents, (c) does not require a special reducing reagent, (d) is fairly insensitive to the presence of
    开发了一种有效的烯烃与α-烷基硫代乙酸酯的无还原光化学羧甲基化方法,该方法(a)是一种实验简单的技术,可提供中等至良好收率的脂肪酸取代衍生物,(b)与极性/质子官能团相容,并且溶剂,(c)不需要特殊的还原剂,(d)对溶解氧的存在相当不敏感,并且通常不需要在辐照前进行脱气。该机制在短暂的MES的“磁阻”的关键特征•到基团转移,导致从介质夺氢。
  • A Mild and Versatile Method for the Tetrahydropyranylation of Alcohols and Their Detetrahydropyranylation
    作者:J. S. Yadav、Dale Srinivas、Gondi Sudershan Reddy
    DOI:10.1080/00397919808006838
    日期:1998.4
    Abstract An efficient and mild method for tetrahydropyranylation of alcohols and their detetrahydropranylation using NH4Cl is described. This protocol provides a useful alternative tetrahydropyranylation of alcohols and their deprotection at different pH. IICT Communication No. 3709
    摘要 描述了一种使用 NH4Cl 进行醇四氢吡喃化及其脱四氢吡喃化的高效、温和的方法。该协议提供了一种有用的替代四氢吡喃醇及其在不同 ph 值下的脱保护。IICT 通讯第 3709 号
  • Lactonization of Hydroxy Ester over Hydrous Zirconium(IV) Oxide Modified by Trimethylsilyl Chloride
    作者:Hideyuki Kuno、Makoto Shibagaki、Kyoko Takahashi、Hajime Matsushita
    DOI:10.1246/bcsj.66.1305
    日期:1993.4
    The lactonization of hydroxy esters was performed over hydrous zirconium(IV) oxide modified by trimethylsilyl chloride. In the case of both primary and secondary hydroxy esters, lactones were obtained in high yield. In addition, it was elucidated that modified-hydrous zirconium(IV) oxide is superior to hydrous zirconium(IV) oxide regarding selectivity in lactonization.
    羟基酯的环酯化是在由化三甲基硅烷修饰的合四氧化锆上进行的。对于初级和次级羟基酯,均获得了高产率的环酯。此外,研究表明,修饰后的合四氧化锆在环酯化选择性方面优于合四氧化锆
  • Lactonization of ω-Hydroxy Esters over Hydrous Zirconium(IV) Oxide
    作者:Hideyuki Kuno、Makoto Shibagaki、Kyoko Takahashi、Ichiro Honda、Hajime Matsushita
    DOI:10.1246/cl.1992.571
    日期:1992.4
    The lactonization of ω-hydroxy esters was carried out by catalysis with hydrous zirconium(IV) oxide. In the flow reaction system, ω-hydroxy esters were efficiently converted to give the corresponding lactones. In particular, it is noteworthy that heptanolide is obtained in good yield. In addition, it is possible to produce a large quantity of lactones in this catalyst system.
    ω-羟基酯的内酯化是通过氧化锆 (IV) 的催化进行的。在流动反应系统中,ω-羟基酯被有效地转化为相应的内酯。特别值得注意的是,以良好的收率获得了庚内酯。此外,在该催化剂体系中可以产生大量的内酯。
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