8-苯氧基辛酸 | 7305-68-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 8-苯氧基辛酸
• 英文名称: 8-phenoxyoctanoic acid
• 英文别名: 8-phenoxy-octanoic acid；8-Phenoxy-octansaeure
• CAS: 7305-68-2
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: WXBSZFQIKPSFNJ-UHFFFAOYSA-N

物化性质

• 熔点：
  69-70 °C
• 沸点：
  390.4±25.0 °C(Predicted)
• 密度：
  1.056±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-苯氧基辛酸 在 乙醇 、 硫酸 、 sodium 作用下， 生成 8-phenoxyoctan-1-ol
  参考文献：
  名称：

  Quaternary Ammonium Salts from Halogenated Alkyl Dimethylamines. III. Omega-Bromo-Heptyl-, -Octyl-, -Nonyl- and -Decyl-dimethylamines

  摘要：

  DOI：

  10.1021/ja01332a030
• 作为产物：
  描述：

  sodium phenoxide 在 sodium hydroxide 、 乙醇 、 水 、 sodium ethanolate 作用下， 生成 8-苯氧基辛酸
  参考文献：
  名称：

  Buckle; Pattison; Saunders, Journal of the Chemical Society, 1949, p. 1475

  摘要：

  DOI：

文献信息

• Enantioselective biomimetic transamination of α-keto acids catalyzed by H4-naphthalene-derived axially chiral biaryl pyridoxamines
  作者：Chengkang Hou、Guoqing Zhao、Dongfang Xu、Baoguo Zhao

  DOI：10.1016/j.tetlet.2018.01.089

  日期：2018.3

  Asymmetric biomimetic transamination is a highly attractive method for synthesis of chemically and biologically important chiral amino acids and chiral amines. Development of chiral pyridoxamines/pyridoxals is the key for the reaction. New axially chiral biaryl pyridoxamines based on H4-naphathene skeleton have been developed. The pyridoxamines display good enantioselectivity and high catalytic activity

  不对称仿生转氨反应是合成化学和生物学上重要的手性氨基酸和手性胺的极具吸引力的方法。手性吡ido胺/吡rid醛的开发是反应的关键。已经开发了基于H 4-萘基骨架的新的轴向手性联芳基吡ido胺。吡ido胺在α-酮酸的不对称仿生转氨反应中表现出良好的对映选择性和高催化活性，可提供多种旋光性非天然氨基酸，产率为61-98％，ee可达91％。
• [EN] 2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS<br/>[FR] AGENTS ANTIFONGIQUES À BASE DE 2-AMINO-1,3,4-THIADIAZINE ET DE 2-AMINO-1,3,4-OXADIAZINE
  申请人：F2G LTD

  公开号：WO2017009651A1

  公开（公告）日：2017-01-19

  The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

  该发明提供了一种化合物，其为式(I)的二氮杂环化合物或其互变异构体，或其药学上可接受的盐，用作抗真菌剂：(I)其中X、N'、C'、A和E如本文所定义。该发明还提供了一种如本文所定义的式(I)的化合物。
• Method of inhibiting parasitic activity
  申请人：Washington University

  公开号：US05747537A1

  公开（公告）日：1998-05-05

  A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

  公开了一种抑制寄生活动的方法，其中可以通过将含有各种杂原子、取代基和不饱和键的肉豆蔻酸选择性类似物纳入所述寄生物的磷脂酰肌醇糖基磷脂酰肌醇（GPI）锚中来影响所述寄生物的生物合成、结构和/或功能，其中包括酯含类似物、酮羰基含类似物、硫含类似物、双键和三键含类似物、芳香基含类似物、硝基类似物和卤代类似物。
• Polyhydroxyalkanoate, method for production thereof and microorganisms for use in the same
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20040067576A1

  公开（公告）日：2004-04-08

  A polyhydroxyalkanoate having a monomer unit composition represented by General Formula (1): A m B (1−m) (1) wherein A is represented by General Formula (2), B is at least one selected from the group consisting of monomer units represented by General Formula (3) or (4), and m has a value of 0.01 or larger and smaller than 1: 1 wherein n has a value of 0 to 10, k has a value of 3 or 5, and R is at least one group selected from the group consisting of groups represented by General Formulae (5) to (7): 2 in Formula (5) R1 is a group selected from the group consisting of a hydrogen atom (H), halogen atoms, —CN, —NO 2 , —CF 3 , —C 2 F 5 . and —C 3 F 7 ; and q is an integer selected from 1 to 8; in Formula (6) R2 is a group selected from the group consisting of a hydrogen atom (H), halogen atoms, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 ; and r is an integer selected from 1 to 8; in Formula (7) R3 is a group selected from the group consisting of a hydrogen atom (H), halogen atoms, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 ; and s is an integer selected from 1 to 8. The efficient production methods are also provided.

  一种聚羟基脂肪酸酯，其单体单元组成由通式（1）表示：AmB（1-m）（1）其中，A由通式（2）表示，B至少选自通式（3）或（4）表示的单体单元组成的群体，m的值大于或等于0.01且小于1:1。其中n的值为0到10，k的值为3或5，R至少选自通式（5）到（7）表示的群体中的一种：2在公式（5）中，R1选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的群体，q为1到8之间的整数；在公式（6）中，R2选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的群体，r为1到8之间的整数；在公式（7）中，R3选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的群体，s为1到8之间的整数。同时还提供了高效的生产方法。
• Polyhydroxyalkanoates and method of producing them by utilizing mircroorganisms
  申请人：——

  公开号：US20010029039A1

  公开（公告）日：2001-10-11

  A microbial polyhydroxyalkanoate which comprises one or more of monomer units represented by Formula (1), 1 where R is at least one selected from the group represented by any one of Formulas (2), (3) and (4); 2 in Formula (2), R1 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and q is an integer of 1 to 8; in Formula (3), R2 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and r is an integer of 1 to 8; in Formula (4), R3 is selected from the group consisting of hydrogen atom (H), halogen atom, —CN, —NO 2 , —CF 3 , —C 2 F 5 and —C 3 F 7 , and s is an integer of 1 to 8. The production method is also disclosed.

  一种微生物聚羟基烷酸酯，包括由式（1）表示的单体单元中的一个或多个，其中R至少选自式（2）、（3）和（4）所表示的任一组中的一种；在式（2）中，R1选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的一组中，q是1到8的整数；在式（3）中，R2选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的一组中，r是1到8的整数；在式（4）中，R3选自氢原子（H）、卤素原子、—CN、—NO2、—CF3、—C2F5和—C3F7组成的一组中，s是1到8的整数。同时公开了生产方法。