2-[[(9Z,12Z)-9,12-Octadecadienyl]oxy]ethanol | 17367-08-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[[(9Z,12Z)-9,12-Octadecadienyl]oxy]ethanol
• 英文别名: 2-octadeca-9,12-dienoxyethanol
• CAS: 17367-08-7
• 化学式: C₂₀H₃₈O₂
• 分子量: 310.5
• InChiKey: LPJRIXGJBNDMDD-UHFFFAOYSA-N

物化性质

• 沸点：
  415.8±33.0 °C(Predicted)
• 密度：
  0.887±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• CATIONIC LIPID
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US20150174261A1

  公开（公告）日：2015-06-25

  Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R 1 is alkenyl or the like, R 2 is alkenyl or the like, R 3 and R 4 are each alkyl, or are combined together to form alkylene, or R 3 and R 5 are combined together to form alkylene, R 5 is a hydrogen atom or the like, or is combined together with R 3 to form alkylene, X 1 is alkylene, and X 2 is a single bond or alkylene).

  提供了一种阳离子脂质，可促进核酸（例如，细胞或类似物质）的引入；一种含有该阳离子脂质和核酸的组合物；通过使用含有该阳离子脂质和核酸的组合物将核酸引入细胞的方法；等等。该阳离子脂质是例如由式(A)表示的阳离子脂质：式(A)：（其中，R1是烯基或类似物，R2是烯基或类似物，R3和R4分别是烷基，或结合在一起形成亚烷基，或R3和R5结合在一起形成亚烷基，R5是氢原子或类似物，或与R3结合在一起形成亚烷基，X1是烷基，X2是单键或烷基）。
• Cationic lipid
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：US10342758B2

  公开（公告）日：2019-07-09

  Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R1 is alkenyl or the like, R2 is alkenyl or the like, R3 and R4 are each alkyl, or are combined together to form alkylene, or R3 and R5 are combined together to form alkylene, R5 is a hydrogen atom or the like, or is combined together with R3 to form alkylene, X1 is alkylene, and X2 is a single bond or alkylene).

  本文提供了一种有助于将核酸导入细胞等的阳离子脂质；一种含有该阳离子脂质和核酸的组合物；一种通过使用含有该阳离子脂质和核酸的组合物将核酸导入细胞的方法等。例如，阳离子脂质是由式（A）表示的阳离子脂质： 式（A）： (其中 R1 是烯基或类似物，R2 是烯基或类似物，R3 和 R4 各自是烷基，或结合在一起形成亚烷基，或 R3 和 R5 结合在一起形成亚烷基，R5 是氢原子或类似物，或与 R3 结合在一起形成亚烷基，X1 是亚烷基，X2 是单键或亚烷基）。
• NOVEL LIPID
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3020701B1

  公开（公告）日：2018-09-26
• EP2871178B1
  申请人：——

  公开号：EP2871178B1

  公开（公告）日：2020-12-23
• ALKYL SUBSTITUTED AZETIDINES AS CATIONIC LIPID
  申请人：Kyowa Kirin Co., Ltd.

  公开号：EP3162794B1

  公开（公告）日：2020-09-16