1,2,3,4-Tetramethoxybutan | 29747-79-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2,3,4-Tetramethoxybutan
• 英文别名: 1,2,3,4-tetramethoxy-butane；1,2,3,4-Tetramethoxybutane
• CAS: 29747-79-3
• 化学式: C₈H₁₈O₄
• mdl: MFCD08276426
• 分子量: 178.229
• InChiKey: UOTINMFZLVZNEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-2-(trimethylsilyloxy)-3-pentanone 、 (R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛 、 1,2,3,4-Tetramethoxybutan 生成 (6R)-2,4-Dimethyl-5-hydroxy-6,7-O-isopropylidene-2-<(trimethylsilyl)oxy>-3-heptanone
  参考文献：
  名称：

  HEATHCOCK, C. H.;WHITE, C. T.;MORRISON, J. J.;VANDERVEER, D., J. ORG. CHEM., 1981, 46, N 7, 1296-1309

  摘要：

  DOI：

文献信息

• AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
  申请人：Shishido Yuji

  公开号：US20120088746A1

  公开（公告）日：2012-04-12

  Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

  披露了具有以下公式表示的化合物：公式（I）。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如疼痛、炎症、创伤性损伤等。
• 3-Amino-2-hydroxybornane derivatives, asymmetric Michael reaction using the same, and process for preparing optically active muscone utilizing Michael reaction
  申请人：NIKKO KYODO CO., LTD.

  公开号：EP0431955A2

  公开（公告）日：1991-06-12

  A 3-amino-2-hydroxybornane derivative represented by formula (I): wherein R represents a furfuryl group, a 1-methylpyrrolylmethyl group, or a benzyl group, is disclosed. The compound is useful as a ligand in an asymmetric Michael reaction, particularly for the production of an optically active muscone.

  由式(I)代表的 3-氨基-2-羟基降冰片烷衍生物： 其中 R 代表糠基、1-甲基吡咯甲基或苄基、 公开了该化合物。该化合物可用作不对称迈克尔反应中的配体，特别是用于生产具有光学活性的麝香酮。
• POLYOXYETHYLENE DERIVATIVE HAVING A PLURALITY OF HYDROXYL GROUPS AT END
  申请人：NOF Corporation

  公开号：EP2692771A1

  公开（公告）日：2014-02-05

  The present invention provides a novel polyoxyethylene derivative having plural hydroxyl groups at a terminal end thereof, particularly a polyoxyethylene derivative having plural hydroxyl groups at a terminal end thereof, which can be effectively used in uses for modifying bio-related substances and can be industrially produced. A polyoxyethylene derivative represented by the formula (1) : wherein a whole molecular weight of the polyoxyethylene derivative is 500 to 160, 000; n is 5 to 3650; L1, L2, and L3 each independently represent an alkylene group, a phenylene group, an ester bond, an amide bond, an ether bond, a urethane bond, a carbonate bond, a secondary amino group, or a combination thereof; X represents a functional group capable of reacting with a bio-related substance; Y represents a hydrophilic group having plural hydroxyl groups made from a residual group of xylitol or volemitol or a residual group of polyglycerin of trimer to 31-mer; Z represents a residual group of a compound having 2 to 5 active hydrogen atoms; b and c are as follows: 1≤b≤4, 1≤c≤4, and 2≤b+c≤5; and d and e each independently are 0 or 1.

  本发明提供了一种新型聚氧乙烯衍生物，其末端具有多个羟基，特别是一种末端具有多个羟基的聚氧乙烯衍生物，可有效地用于改性生物相关物质，并可工业化生产。 由式（1）代表的聚氧乙烯衍生物 ： 其中，聚氧乙烯衍生物的全分子量为 500 至 160，000；n 为 5 至 3650；L1、L2 和 L3 各自独立地代表亚烷基、亚苯基、酯键、酰胺键、醚键、聚氨酯键、碳酸酯键、仲氨基或它们的组合；X 代表能与生物相关物质反应的官能团； Y 代表具有多个羟基的亲水基团，由木糖醇或 Volemitol 的残留基团或三聚体至 31 聚体的聚甘油的残留基团构成； Z 代表具有 2 至 5 个活性氢原子的化合物的残留基团； b 和 c 如下：1≤b≤4，1≤c≤4，2≤b+c≤5；d和e各自独立地为0或1。
• SURFACE TREATMENT AGENT
  申请人：Daikin Industries, Ltd.

  公开号：EP3309164B1

  公开（公告）日：2020-09-02
• Method of Relieving, Improving, Preventing or Treating Xerostomia
  申请人：SUNBIO INC.

  公开号：US20140155457A1

  公开（公告）日：2014-06-05

  Provided is a method of relieving, improving, preventing or treating xerostomia including applying an oral cavity composition including a polyethylene glycol (PEG) derivative whose reactor is modified to form a covalent bond with an epithelial cell of the oral cavity. An oral moisturizing effect and moisture persistency are increased and the method is effective against xerostomia due to aging or disease.