2-hydrazino-5-phenylthiazolecarboxylic acid hydrochloride | 136744-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-hydrazino-5-phenylthiazolecarboxylic acid hydrochloride
• 英文别名: 2-hydrazino-5-phenyl-4-carboxythiazole hydrochloride；2-Hydrazinyl-5-phenyl-1,3-thiazol-3-ium-4-carboxylic acid;chloride；2-hydrazinyl-5-phenyl-1,3-thiazol-3-ium-4-carboxylic acid;chloride
• CAS: 136744-22-4
• 化学式: C₁₀H₉N₃O₂S*ClH
• 分子量: 271.727
• InChiKey: KOUQOGMBPHBXAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-hydrazino-4-methoxycarbonyl-5-phenylthiazole 在 盐酸 作用下， 以 水 为溶剂， 反应 5.0h， 以73%的产率得到2-hydrazino-5-phenylthiazolecarboxylic acid hydrochloride
  参考文献：
  名称：

  Reaction of methyl 3-phenyl-3-chloro-2-oxopropionate with thiosemicarbazones

  摘要：

  The reaction of methyl 3-phenyl-3-chloro-2-oxopropionate with thiosemicarbazones proceeds via the intermediate formation of methyl [S-(1'-alkylideneiso-thiosemicarbazidyl)]-3-phenyl-2-oxopropionate hydrochlorides, which then cyclize to novel 4-methoxycarbonyl-5-phenyl-2-substituted thiazoles. Hydrolysis of the intermediate products and the thiazoles obtained therefrom with simultaneous distillation of the carbonyl compound affords 2-hydrazino-4-methoxycarbonyl-5-phenylthiazole.

  DOI：

  10.1007/bf00961310

文献信息

• Synthesis and reactions of 2-amino-5-carbomethoxy-6-phenyl-6H-1,3,4-thiadiazine
  作者：V. A. Mamedov、L. V. Krokhina、E. A. Berdnikov、Ya. A. Levin

  DOI：10.1007/bf01164718

  日期：1996.9
• Reaction of methyl 3-phenyl-3-chloro-2-oxopropionate with thiosemicarbazones
  作者：V. A. Mamedov、V. N. Valeeva、L. A. Antokhina、I. A. Nuretdinov

  DOI：10.1007/bf00961310

  日期：1991.6

  The reaction of methyl 3-phenyl-3-chloro-2-oxopropionate with thiosemicarbazones proceeds via the intermediate formation of methyl [S-(1'-alkylideneiso-thiosemicarbazidyl)]-3-phenyl-2-oxopropionate hydrochlorides, which then cyclize to novel 4-methoxycarbonyl-5-phenyl-2-substituted thiazoles. Hydrolysis of the intermediate products and the thiazoles obtained therefrom with simultaneous distillation of the carbonyl compound affords 2-hydrazino-4-methoxycarbonyl-5-phenylthiazole.