Ethyl 2-[(2-acetyloxy-2-phenylacetyl)amino]acetate | 1022081-09-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethyl 2-[(2-acetyloxy-2-phenylacetyl)amino]acetate
• CAS: 1022081-09-9
• 化学式: C₁₄H₁₇NO₅
• 分子量: 279.293
• InChiKey: FEMZFAMJOGWXIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  异氰基乙酸乙酯 、 苯甲醛 、 溶剂黄146 反应 24.0h， 以86%的产率得到Ethyl 2-[(2-acetyloxy-2-phenylacetyl)amino]acetate
  参考文献：
  名称：

  Solvent‐Free Passerini Reactions

  摘要：

  The influence of the substrate structure and concentration on the yield of the Passerini reaction was studied. A new, solvent-free methodology for a convenient preparation of alpha-acyloxyamides 4 was established and compared to the classical methodology. A higher reaction yield was obtained in shorter time, especially in the case of aromatic aldehydes.

  DOI：

  10.1080/00397910701863608

文献信息

• Solvent‐Free Passerini Reactions
  作者：Dominik Koszelewski、Wiktor Szymanski、Joanna Krysiak、Ryszard Ostaszewski

  DOI：10.1080/00397910701863608

  日期：2008.3.1

  The influence of the substrate structure and concentration on the yield of the Passerini reaction was studied. A new, solvent-free methodology for a convenient preparation of alpha-acyloxyamides 4 was established and compared to the classical methodology. A higher reaction yield was obtained in shorter time, especially in the case of aromatic aldehydes.