5-bromo-N-(3-bromo-4-((1-methylpiperidin-3-yl)methoxy)phenethyl)furan-2-carboxamide | 1199814-66-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-bromo-N-(3-bromo-4-((1-methylpiperidin-3-yl)methoxy)phenethyl)furan-2-carboxamide
• 英文别名: N-(3-bromo-4-((1-methylpiperidin-3-yl)methoxy)phenethyl)-5-bromofuran-2-carboxamide；5-bromo-N-[2-[3-bromo-4-[(1-methylpiperidin-3-yl)methoxy]phenyl]ethyl]furan-2-carboxamide
• CAS: 1199814-66-8
• 化学式: C₂₀H₂₄Br₂N₂O₃
• 分子量: 500.23
• InChiKey: GALIMZYQAGRPHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(氯甲基)-1-甲基哌啶 、 5-bromo-N-(3-bromo-4-hydroxyphenethyl)furan-2-carboxamide 在 caesium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 5-bromo-N-(3-bromo-4-((1-methylpiperidin-3-yl)methoxy)phenethyl)furan-2-carboxamide
  参考文献：
  名称：

  一类新的 H3 拮抗剂来源于天然产物指导合成的海洋溴吡咯生物碱双吡啉的非天然类似物

  摘要：

  这封信描述了天然产物引导合成的海洋溴吡咯生物碱 dispyrin 的非天然类似物，以及由此产生的 H 3拮抗作用的SAR 。多轮迭代平行合成将人类 H 3 IC提高了50 ∼33 倍，并提供了一类新的 H 3拮抗剂，该拮抗剂基于新的双吡啉溴酪胺核心。

  DOI：

  10.1016/j.bmcl.2009.04.106

文献信息

• RAPAMYCIN CARBONATE ESTERS
  申请人：Rhodes Alan

  公开号：US20090253733A1

  公开（公告）日：2009-10-08

  Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.

  某些实施例包括通过脂肪酶催化的区域特异性过程合成的罗法昔明在第42位的碳酸酯。这些化合物或其药用可接受的盐在器官和组织移植排斥、自身免疫疾病、增殖性疾病、再狭窄、癌症或微生物感染的治疗中是有用的。
• [EN] UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF<br/>[FR] ANALOGUES DE DYSPYRINE NON NATURELS, LEURS PRÉPARATIONS ET LEURS UTILISATIONS
  申请人：UNIV VANDERBILT

  公开号：WO2009152071A1

  公开（公告）日：2009-12-17

  Disclosed are dispyrin analogue compounds useful as H3 receptor activity modulators, methods of making same, pharmaceutical compositions comprising same, and methods of treating neurological and psychiatric disorders associated with histamine H3 receptor activity using same. In one aspect, the disclosed analogues can have a structure represented by a formula: (I), This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开揭示了作为H3受体活性调节剂有用的dispyrin类似化合物，制备方法，包含同样化合物的药物组合物，以及使用同样化合物治疗与组胺H3受体活性相关的神经和精神障碍的方法。在一个方面，所公开的类似物可以具有以下式表示的结构：（I）。本摘要旨在作为在特定领域进行搜索的扫描工具，不打算限制本发明。
• UNNATURAL DISPYRIN ANALOGUES, PREPARATION AND USES THEREOF
  申请人：Lindsley Craig W.

  公开号：US20100035929A1

  公开（公告）日：2010-02-11

  Disclosed are dispyrin analogue compounds useful as H3 receptor activity modulators, methods of making same, pharmaceutical compositions comprising same, and methods of treating neurological and psychiatric disorders associated with histamine H3 receptor activity using same. In one aspect, the disclosed analogues can have a structure represented by a formula: This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin
  作者：J. Phillip Kennedy、P. Jeffrey Conn、Craig W. Lindsley

  DOI：10.1016/j.bmcl.2009.04.106

  日期：2009.6

  Letter describes the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin, and the resulting SAR of H3 antagonism. Multiple rounds of iterative parallel synthesis improved human H3 IC50 ∼33-fold, and afforded a new class of H3 antagonists based on the novel bromotyramine core of dispyrin.

  这封信描述了天然产物引导合成的海洋溴吡咯生物碱 dispyrin 的非天然类似物，以及由此产生的 H 3拮抗作用的SAR 。多轮迭代平行合成将人类 H 3 IC提高了50 ∼33 倍，并提供了一类新的 H 3拮抗剂，该拮抗剂基于新的双吡啉溴酪胺核心。