N-(4-phenoxy-phenacyl)-phthalimide | 861018-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-phenoxy-phenacyl)-phthalimide
• 英文别名: N-(4-Phenoxy-phenacyl)-phthalimid；2-[2-Oxo-2-(4-phenoxyphenyl)ethyl]isoindole-1,3-dione
• CAS: 861018-39-5
• 化学式: C₂₂H₁₅NO₄
• 分子量: 357.365
• InChiKey: GYFWBXFFIVOTPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-phenoxy-phenacyl)-phthalimide 在 palladium on activated charcoal 四(三苯基膦)钯 、 氨 、 氢气 、 sodium methylate 、 sodium ethanolate 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 39.0h， 生成 (1SR,3RS)-cis-3-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclopentanol
  参考文献：
  名称：

  Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

  摘要：

  Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00441-8
• 作为产物：
  描述：

  4'-苯氧基苯乙酮 在 pyridinium hydrobromide perbromide 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 N-(4-phenoxy-phenacyl)-phthalimide
  参考文献：
  名称：

  Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

  摘要：

  Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00441-8

文献信息

• Tomita, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1937, vol. 57, p. 609,614; dtsch. Ref. S. 131, 135
  作者：Tomita

  DOI：——

  日期：——
• Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I
  作者：Lee D Arnold、David J Calderwood、Richard W Dixon、David N Johnston、Joanne S Kamens、Rainer Munschauer、Paul Rafferty、Sheldon E Ratnofsky

  DOI：10.1016/s0960-894x(00)00441-8

  日期：2000.10

  Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of lck in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells. (C) 2000 Elsevier Science Ltd. All rights reserved.