6-Methoxy-3-oxohexanenitrile | 884343-75-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-Methoxy-3-oxohexanenitrile
• CAS: 884343-75-3
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: QBWHLFREPSOXGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-Methoxy-3-oxohexanenitrile 在 肼 作用下， 以 乙醇 为溶剂， 生成 5-(3-甲氧基丙基)-1H-吡唑-3-胺
  参考文献：
  名称：

  Novel Compounds

  摘要：

  提供了一个化合物，其化学式为(I)：制备方法、药物组合物以及在治疗中的用途。

  公开号：

  US20080004302A1
• 作为产物：
  描述：

  4-甲氧基丁酸甲酯 在 sodium hydride 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 生成 6-Methoxy-3-oxohexanenitrile
  参考文献：
  名称：

  Novel Compounds

  摘要：

  提供了一个化合物，其化学式为(I)：制备方法、药物组合物以及在治疗中的用途。

  公开号：

  US20080004302A1

文献信息

• Surgical adhesive compostion and process for enhanced tissue closure and healing
  申请人：Pollock Freas Jacob

  公开号：US20070092483A1

  公开（公告）日：2007-04-26

  A surgical tissue adhesive composition contains at least one 1,1-disubstituted electron-deficient olefin macromer. The adhesive composition of the invention has improved biocompatibility as well as controlled biodegradation characteristics and bioactivity. Adhesive co-monomer compositions contain at least one macromer with a pendant oligomer, polymer, or peptide chain as an acrylic ester of the reactive olefin. The polymers formed therefrom have a grafted brush-like nature. The composition is particularly useful for creating an adhesive bond at the junction of living tissue in surgical applications. The adhesive composition may further comprise co-monomer, co-macromer, cross-linker, or inter-penetrating polymer compounds containing peptide sequences that are bioactive or enzyme responsive. The peptide sequences are selected to promote tissue infiltration and healing in a particular biological tissue. The sequences may contain specific cell-adhesion, cell-signaling, and enzyme-cleavable domains. Furthermore, a degradable filler material may be included in the composition to create a reinforced composite. The filler preferably has a higher degradation rate than the polymer matrix, generating porosity upon degradation. The adhesive may further contain entrapped or incorporated drugs or biologics, including antibiotics or growth factors. The adhesive can be used to bind together the edges of living tissues during surgical procedures. The cured composition provides interfacial bonding and mechanical fixation while promoting tissue infiltration and replacement of the adhesive polymer.
• US8138272B2
  申请人：——

  公开号：US8138272B2

  公开（公告）日：2012-03-20
• Novel Compounds
  申请人：Theoclitou Maria-Elena

  公开号：US20080004302A1

  公开（公告）日：2008-01-03

  There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.

  提供了一个化合物，其化学式为(I)：制备方法、药物组合物以及在治疗中的用途。