6-O-Methyldeoxyguanosine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-O-Methyldeoxyguanosine
• 英文别名: (2R,3R,5R)-5-(2-amino-6-methoxypurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• 化学式: C₁₁H₁₅N₅O₄
• 分子量: 281.27
• InChiKey: BCKDNMPYCIOBTA-FSDSQADBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Novel NNA-DNA Adducts as Biomarkers for Detecting Exposure to Thirdhand Smoke
  申请人：Hang Bo

  公开号：US20160039859A1

  公开（公告）日：2016-02-11

  NNA-derived specific adducts represent an integrated biomarker of exposure to thirdhand smoke (THS) as NNA is unique to THS. The NNA-dG covalent binding adduct could serve as such a biomarker, and play a role in identifying individuals exposed to THS, thus providing critical information for early detection and prevention.
• NUCLEOTIDE PRODRUGS
  申请人：CERECOR, INC.

  公开号：US20210139525A1

  公开（公告）日：2021-05-13

  The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof. The invention further relates using the prodrugs of the invention in the treatment of mitochondrial DNA (mtDNA) depletion syndrome (MDS).